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Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression
Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive functi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neuropsychiatric Association
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639143/ https://www.ncbi.nlm.nih.gov/pubmed/29042900 http://dx.doi.org/10.4306/pi.2017.14.5.708 |
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author | Lee, Kanghee Han, Ji Won Kim, Ki Woong |
author_facet | Lee, Kanghee Han, Ji Won Kim, Ki Woong |
author_sort | Lee, Kanghee |
collection | PubMed |
description | Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with major depressive disorder (MDD) and compared the EEG relative powers of 9 scalp regions. Compared to the MDD group, the AD group had a higher global theta relative power (p=0.021). In the MDD group, beta relative power was higher in the mid-central region than in the left or right central regions (p<0.01). The prediction model that included global theta relative power and regional beta index was able to discriminate AD from MDD (AUC=0.893, p=0.002). A combination of global theta relative power and intra-individual regional differences in beta may differentiate early AD from MDD with cognitive impairment. |
format | Online Article Text |
id | pubmed-5639143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Neuropsychiatric Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-56391432017-10-17 Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression Lee, Kanghee Han, Ji Won Kim, Ki Woong Psychiatry Investig Brief Report Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with major depressive disorder (MDD) and compared the EEG relative powers of 9 scalp regions. Compared to the MDD group, the AD group had a higher global theta relative power (p=0.021). In the MDD group, beta relative power was higher in the mid-central region than in the left or right central regions (p<0.01). The prediction model that included global theta relative power and regional beta index was able to discriminate AD from MDD (AUC=0.893, p=0.002). A combination of global theta relative power and intra-individual regional differences in beta may differentiate early AD from MDD with cognitive impairment. Korean Neuropsychiatric Association 2017-09 2017-09-11 /pmc/articles/PMC5639143/ /pubmed/29042900 http://dx.doi.org/10.4306/pi.2017.14.5.708 Text en Copyright © 2017 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Lee, Kanghee Han, Ji Won Kim, Ki Woong Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression |
title | Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression |
title_full | Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression |
title_fullStr | Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression |
title_full_unstemmed | Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression |
title_short | Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression |
title_sort | regional beta index of electroencephalography may differentiate alzheimer's disease from depression |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639143/ https://www.ncbi.nlm.nih.gov/pubmed/29042900 http://dx.doi.org/10.4306/pi.2017.14.5.708 |
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