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Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression

Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive functi...

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Detalles Bibliográficos
Autores principales: Lee, Kanghee, Han, Ji Won, Kim, Ki Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639143/
https://www.ncbi.nlm.nih.gov/pubmed/29042900
http://dx.doi.org/10.4306/pi.2017.14.5.708
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author Lee, Kanghee
Han, Ji Won
Kim, Ki Woong
author_facet Lee, Kanghee
Han, Ji Won
Kim, Ki Woong
author_sort Lee, Kanghee
collection PubMed
description Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with major depressive disorder (MDD) and compared the EEG relative powers of 9 scalp regions. Compared to the MDD group, the AD group had a higher global theta relative power (p=0.021). In the MDD group, beta relative power was higher in the mid-central region than in the left or right central regions (p<0.01). The prediction model that included global theta relative power and regional beta index was able to discriminate AD from MDD (AUC=0.893, p=0.002). A combination of global theta relative power and intra-individual regional differences in beta may differentiate early AD from MDD with cognitive impairment.
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spelling pubmed-56391432017-10-17 Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression Lee, Kanghee Han, Ji Won Kim, Ki Woong Psychiatry Investig Brief Report Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with major depressive disorder (MDD) and compared the EEG relative powers of 9 scalp regions. Compared to the MDD group, the AD group had a higher global theta relative power (p=0.021). In the MDD group, beta relative power was higher in the mid-central region than in the left or right central regions (p<0.01). The prediction model that included global theta relative power and regional beta index was able to discriminate AD from MDD (AUC=0.893, p=0.002). A combination of global theta relative power and intra-individual regional differences in beta may differentiate early AD from MDD with cognitive impairment. Korean Neuropsychiatric Association 2017-09 2017-09-11 /pmc/articles/PMC5639143/ /pubmed/29042900 http://dx.doi.org/10.4306/pi.2017.14.5.708 Text en Copyright © 2017 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Lee, Kanghee
Han, Ji Won
Kim, Ki Woong
Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression
title Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression
title_full Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression
title_fullStr Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression
title_full_unstemmed Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression
title_short Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression
title_sort regional beta index of electroencephalography may differentiate alzheimer's disease from depression
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639143/
https://www.ncbi.nlm.nih.gov/pubmed/29042900
http://dx.doi.org/10.4306/pi.2017.14.5.708
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