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Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice

The introduction of megabase-sized large DNA fragments into the germline has been a difficult task. Although microcell-mediated chromosome transfer into mouse embryonic stem cells (ESCs) allows the production of transchromosomic mice, ESCs have unstable karyotypes and germline transmission is unreli...

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Detalles Bibliográficos
Autores principales:	Shinohara, Takashi, Kazuki, Kanako, Ogonuki, Narumi, Morimoto, Hiroko, Matoba, Shogo, Hiramatsu, Kei, Honma, Kazuhisa, Suzuki, Teruhiko, Hara, Takahiko, Ogura, Atsuo, Oshimura, Mitsuo, Kanatsu-Shinohara, Mito, Kazuki, Yasuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639258/ https://www.ncbi.nlm.nih.gov/pubmed/28943251 http://dx.doi.org/10.1016/j.stemcr.2017.08.012

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