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Spindle Misorientation of Cerebral and Cerebellar Progenitors Is a Mechanistic Cause of Megalencephaly

Misoriented division of neuroprogenitors, by loss-of-function studies of centrosome or spindle components, has been linked to the developmental brain defects microcephaly and lissencephaly. As these approaches also affect centrosome biogenesis, spindle assembly, or cell-cycle progression, the result...

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Detalles Bibliográficos
Autores principales:	Li, Huaibiao, Kroll, Torsten, Moll, Jürgen, Frappart, Lucien, Herrlich, Peter, Heuer, Heike, Ploubidou, Aspasia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639290/ https://www.ncbi.nlm.nih.gov/pubmed/28943256 http://dx.doi.org/10.1016/j.stemcr.2017.08.013

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