Ursolic acid suppresses TGF-β1-induced quiescent HSC activation and transformation by inhibiting NADPH oxidase expression and Hedgehog signaling

Activation of quiescent hepatic stellate cells (q-HSCs) and their transformation to myofibroblasts (MFBs) is a key event in liver fibrosis. Hedgehog (Hh) signaling stimulates q-HSCs to differentiate into MFBs, and NADPH oxidase (NOX) may be involved in regulating Hh signaling. The author's prel...

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Detalles Bibliográficos
Autores principales: Yu, Shan-Shan, Chen, Biao, Huang, Chen-Kai, Zhou, Juan-Juan, Huang, Xin, Wang, An-Jiang, Li, Bi-Min, He, Wen-Hua, Zhu, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639307/
https://www.ncbi.nlm.nih.gov/pubmed/29042951
http://dx.doi.org/10.3892/etm.2017.5001

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