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Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes

A new class of hydrogels utilizing DNA (DNA quadruplex gel) has been constructed by directly and symmetrically coupling deoxynucleotide phosphoramidite monomers to the ends of polyethylene glycols (PEGs) in liquid phase, and using the resulting DNA‐PEG‐DNA triblock copolymers as macromonomers. Elong...

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Autores principales: Tanaka, Shizuma, Wakabayashi, Kenta, Fukushima, Kazuki, Yukami, Shinsuke, Maezawa, Ryuki, Takeda, Yuhei, Tatsumi, Kohei, Ohya, Yuichi, Kuzuya, Akinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639371/
https://www.ncbi.nlm.nih.gov/pubmed/28777486
http://dx.doi.org/10.1002/asia.201701066
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author Tanaka, Shizuma
Wakabayashi, Kenta
Fukushima, Kazuki
Yukami, Shinsuke
Maezawa, Ryuki
Takeda, Yuhei
Tatsumi, Kohei
Ohya, Yuichi
Kuzuya, Akinori
author_facet Tanaka, Shizuma
Wakabayashi, Kenta
Fukushima, Kazuki
Yukami, Shinsuke
Maezawa, Ryuki
Takeda, Yuhei
Tatsumi, Kohei
Ohya, Yuichi
Kuzuya, Akinori
author_sort Tanaka, Shizuma
collection PubMed
description A new class of hydrogels utilizing DNA (DNA quadruplex gel) has been constructed by directly and symmetrically coupling deoxynucleotide phosphoramidite monomers to the ends of polyethylene glycols (PEGs) in liquid phase, and using the resulting DNA‐PEG‐DNA triblock copolymers as macromonomers. Elongation of merely four deoxyguanosine residues on PEG, which produces typically ≈10 grams of desired DNA‐PEG conjugates in one synthesis, resulted in intelligent and biodegradable hydrogels utilizing DNA quadruplex formation, which are responsive to various input signals such as Na(+), K(+), and complementary DNA strand. Gelation of DNA quadruplex gels takes place within a few seconds upon the addition of a trigger, enabling free formation just like Ca(+)‐alginate hydrogels or possible application as an injectable polymer (IP) gel. The obtained hydrogels show good thermal stability and rheological properties, and even display self‐healing ability.
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spelling pubmed-56393712017-10-25 Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes Tanaka, Shizuma Wakabayashi, Kenta Fukushima, Kazuki Yukami, Shinsuke Maezawa, Ryuki Takeda, Yuhei Tatsumi, Kohei Ohya, Yuichi Kuzuya, Akinori Chem Asian J Communications A new class of hydrogels utilizing DNA (DNA quadruplex gel) has been constructed by directly and symmetrically coupling deoxynucleotide phosphoramidite monomers to the ends of polyethylene glycols (PEGs) in liquid phase, and using the resulting DNA‐PEG‐DNA triblock copolymers as macromonomers. Elongation of merely four deoxyguanosine residues on PEG, which produces typically ≈10 grams of desired DNA‐PEG conjugates in one synthesis, resulted in intelligent and biodegradable hydrogels utilizing DNA quadruplex formation, which are responsive to various input signals such as Na(+), K(+), and complementary DNA strand. Gelation of DNA quadruplex gels takes place within a few seconds upon the addition of a trigger, enabling free formation just like Ca(+)‐alginate hydrogels or possible application as an injectable polymer (IP) gel. The obtained hydrogels show good thermal stability and rheological properties, and even display self‐healing ability. John Wiley and Sons Inc. 2017-08-29 2017-09-19 /pmc/articles/PMC5639371/ /pubmed/28777486 http://dx.doi.org/10.1002/asia.201701066 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Tanaka, Shizuma
Wakabayashi, Kenta
Fukushima, Kazuki
Yukami, Shinsuke
Maezawa, Ryuki
Takeda, Yuhei
Tatsumi, Kohei
Ohya, Yuichi
Kuzuya, Akinori
Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes
title Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes
title_full Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes
title_fullStr Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes
title_full_unstemmed Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes
title_short Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes
title_sort intelligent, biodegradable, and self‐healing hydrogels utilizing dna quadruplexes
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639371/
https://www.ncbi.nlm.nih.gov/pubmed/28777486
http://dx.doi.org/10.1002/asia.201701066
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