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Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes
A new class of hydrogels utilizing DNA (DNA quadruplex gel) has been constructed by directly and symmetrically coupling deoxynucleotide phosphoramidite monomers to the ends of polyethylene glycols (PEGs) in liquid phase, and using the resulting DNA‐PEG‐DNA triblock copolymers as macromonomers. Elong...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639371/ https://www.ncbi.nlm.nih.gov/pubmed/28777486 http://dx.doi.org/10.1002/asia.201701066 |
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author | Tanaka, Shizuma Wakabayashi, Kenta Fukushima, Kazuki Yukami, Shinsuke Maezawa, Ryuki Takeda, Yuhei Tatsumi, Kohei Ohya, Yuichi Kuzuya, Akinori |
author_facet | Tanaka, Shizuma Wakabayashi, Kenta Fukushima, Kazuki Yukami, Shinsuke Maezawa, Ryuki Takeda, Yuhei Tatsumi, Kohei Ohya, Yuichi Kuzuya, Akinori |
author_sort | Tanaka, Shizuma |
collection | PubMed |
description | A new class of hydrogels utilizing DNA (DNA quadruplex gel) has been constructed by directly and symmetrically coupling deoxynucleotide phosphoramidite monomers to the ends of polyethylene glycols (PEGs) in liquid phase, and using the resulting DNA‐PEG‐DNA triblock copolymers as macromonomers. Elongation of merely four deoxyguanosine residues on PEG, which produces typically ≈10 grams of desired DNA‐PEG conjugates in one synthesis, resulted in intelligent and biodegradable hydrogels utilizing DNA quadruplex formation, which are responsive to various input signals such as Na(+), K(+), and complementary DNA strand. Gelation of DNA quadruplex gels takes place within a few seconds upon the addition of a trigger, enabling free formation just like Ca(+)‐alginate hydrogels or possible application as an injectable polymer (IP) gel. The obtained hydrogels show good thermal stability and rheological properties, and even display self‐healing ability. |
format | Online Article Text |
id | pubmed-5639371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56393712017-10-25 Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes Tanaka, Shizuma Wakabayashi, Kenta Fukushima, Kazuki Yukami, Shinsuke Maezawa, Ryuki Takeda, Yuhei Tatsumi, Kohei Ohya, Yuichi Kuzuya, Akinori Chem Asian J Communications A new class of hydrogels utilizing DNA (DNA quadruplex gel) has been constructed by directly and symmetrically coupling deoxynucleotide phosphoramidite monomers to the ends of polyethylene glycols (PEGs) in liquid phase, and using the resulting DNA‐PEG‐DNA triblock copolymers as macromonomers. Elongation of merely four deoxyguanosine residues on PEG, which produces typically ≈10 grams of desired DNA‐PEG conjugates in one synthesis, resulted in intelligent and biodegradable hydrogels utilizing DNA quadruplex formation, which are responsive to various input signals such as Na(+), K(+), and complementary DNA strand. Gelation of DNA quadruplex gels takes place within a few seconds upon the addition of a trigger, enabling free formation just like Ca(+)‐alginate hydrogels or possible application as an injectable polymer (IP) gel. The obtained hydrogels show good thermal stability and rheological properties, and even display self‐healing ability. John Wiley and Sons Inc. 2017-08-29 2017-09-19 /pmc/articles/PMC5639371/ /pubmed/28777486 http://dx.doi.org/10.1002/asia.201701066 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Communications Tanaka, Shizuma Wakabayashi, Kenta Fukushima, Kazuki Yukami, Shinsuke Maezawa, Ryuki Takeda, Yuhei Tatsumi, Kohei Ohya, Yuichi Kuzuya, Akinori Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes |
title | Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes |
title_full | Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes |
title_fullStr | Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes |
title_full_unstemmed | Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes |
title_short | Intelligent, Biodegradable, and Self‐Healing Hydrogels Utilizing DNA Quadruplexes |
title_sort | intelligent, biodegradable, and self‐healing hydrogels utilizing dna quadruplexes |
topic | Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639371/ https://www.ncbi.nlm.nih.gov/pubmed/28777486 http://dx.doi.org/10.1002/asia.201701066 |
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