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Supramolecular Chemistry Targeting Proteins

[Image: see text] The specific recognition of protein surface elements is a fundamental challenge in the life sciences. New developments in this field will form the basis of advanced therapeutic approaches and lead to applications such as sensors, affinity tags, immobilization techniques, and protei...

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Autores principales: van Dun, Sam, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639466/
https://www.ncbi.nlm.nih.gov/pubmed/28926241
http://dx.doi.org/10.1021/jacs.7b01979
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author van Dun, Sam
Ottmann, Christian
Milroy, Lech-Gustav
Brunsveld, Luc
author_facet van Dun, Sam
Ottmann, Christian
Milroy, Lech-Gustav
Brunsveld, Luc
author_sort van Dun, Sam
collection PubMed
description [Image: see text] The specific recognition of protein surface elements is a fundamental challenge in the life sciences. New developments in this field will form the basis of advanced therapeutic approaches and lead to applications such as sensors, affinity tags, immobilization techniques, and protein-based materials. Synthetic supramolecular molecules and materials are creating new opportunities for protein recognition that are orthogonal to classical small molecule and protein-based approaches. As outlined here, their unique molecular features enable the recognition of amino acids, peptides, and even whole protein surfaces, which can be applied to the modulation and assembly of proteins. We believe that structural insights into these processes are of great value for the further development of this field and have therefore focused this Perspective on contributions that provide such structural data.
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spelling pubmed-56394662017-10-17 Supramolecular Chemistry Targeting Proteins van Dun, Sam Ottmann, Christian Milroy, Lech-Gustav Brunsveld, Luc J Am Chem Soc [Image: see text] The specific recognition of protein surface elements is a fundamental challenge in the life sciences. New developments in this field will form the basis of advanced therapeutic approaches and lead to applications such as sensors, affinity tags, immobilization techniques, and protein-based materials. Synthetic supramolecular molecules and materials are creating new opportunities for protein recognition that are orthogonal to classical small molecule and protein-based approaches. As outlined here, their unique molecular features enable the recognition of amino acids, peptides, and even whole protein surfaces, which can be applied to the modulation and assembly of proteins. We believe that structural insights into these processes are of great value for the further development of this field and have therefore focused this Perspective on contributions that provide such structural data. American Chemical Society 2017-09-19 2017-10-11 /pmc/articles/PMC5639466/ /pubmed/28926241 http://dx.doi.org/10.1021/jacs.7b01979 Text en Copyright © 2017 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle van Dun, Sam
Ottmann, Christian
Milroy, Lech-Gustav
Brunsveld, Luc
Supramolecular Chemistry Targeting Proteins
title Supramolecular Chemistry Targeting Proteins
title_full Supramolecular Chemistry Targeting Proteins
title_fullStr Supramolecular Chemistry Targeting Proteins
title_full_unstemmed Supramolecular Chemistry Targeting Proteins
title_short Supramolecular Chemistry Targeting Proteins
title_sort supramolecular chemistry targeting proteins
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639466/
https://www.ncbi.nlm.nih.gov/pubmed/28926241
http://dx.doi.org/10.1021/jacs.7b01979
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