Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma

BACKGROUND: KIBRA has been suggested as a key regulator of the Hippo signaling pathway, regulating organ size, cell contact inhibition, tissue regeneration as well as tumorigenesis and cystogenesis. We recently reported that human KIBRA expression depends on a complex alternative CpG-rich promoter s...

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Detalles Bibliográficos
Autores principales: Schelleckes, Katrin, Schmitz, Boris, Ciarimboli, Giuliano, Lenders, Malte, Pavenstädt, Hermann J., Herrmann, Edwin, Brand, Stefan-Martin, Brand, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639574/
https://www.ncbi.nlm.nih.gov/pubmed/29046731
http://dx.doi.org/10.1186/s13148-017-0415-6

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