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Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles
Gold nanoparticles (AuNPs) could serve as potential radiotherapy sensitizers because of their exceptional biocompatibility and high-Z material nature; however, since in vitro and in vivo behaviors of AuNPs are determined not only by their particle size but also by their surface chemistries, whether...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639719/ https://www.ncbi.nlm.nih.gov/pubmed/29034008 http://dx.doi.org/10.1142/S1793545816420037 |
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author | Jiang, Xingya Du, Bujie Yu, Mengxiao Jia, Xun Zheng, Jie |
author_facet | Jiang, Xingya Du, Bujie Yu, Mengxiao Jia, Xun Zheng, Jie |
author_sort | Jiang, Xingya |
collection | PubMed |
description | Gold nanoparticles (AuNPs) could serve as potential radiotherapy sensitizers because of their exceptional biocompatibility and high-Z material nature; however, since in vitro and in vivo behaviors of AuNPs are determined not only by their particle size but also by their surface chemistries, whether surface ligands can affect their radiosensitization has seldom been investigated in the radiosensitization of AuNPs. By conducting head-to-head comparison on radiosensitization of two kinds of ultrasmall (~2 nm) near-infrared (NIR) emitting AuNPs that are coated with zwitterionic glutathione and neutral polyethylene glycol (PEG) ligands, respectively, we found that zwitterionic glutathione coated AuNPs (GS-AuNPs) can reduce survival rates of MCF-7 cells under irradiation of clinically used megavoltage photon beam at low dosage of ~2.25 Gy. On the other hand, PEG-AuNPs can serve as a radiation-protecting agent and enabled MCF-7 cells more resistant to the irradiation, clearly indicating the key role of surface chemistry in radiosensitization of AuNPs. More detailed studies suggested that such difference was independent of cellular uptake and its efficiency, but might be related to the ligand-induced difference in photoelectron generation and/or interactions between AuNPs and X-ray triggered reactive oxygen species (ROS). |
format | Online Article Text |
id | pubmed-5639719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
record_format | MEDLINE/PubMed |
spelling | pubmed-56397192017-10-13 Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles Jiang, Xingya Du, Bujie Yu, Mengxiao Jia, Xun Zheng, Jie J Innov Opt Health Sci Article Gold nanoparticles (AuNPs) could serve as potential radiotherapy sensitizers because of their exceptional biocompatibility and high-Z material nature; however, since in vitro and in vivo behaviors of AuNPs are determined not only by their particle size but also by their surface chemistries, whether surface ligands can affect their radiosensitization has seldom been investigated in the radiosensitization of AuNPs. By conducting head-to-head comparison on radiosensitization of two kinds of ultrasmall (~2 nm) near-infrared (NIR) emitting AuNPs that are coated with zwitterionic glutathione and neutral polyethylene glycol (PEG) ligands, respectively, we found that zwitterionic glutathione coated AuNPs (GS-AuNPs) can reduce survival rates of MCF-7 cells under irradiation of clinically used megavoltage photon beam at low dosage of ~2.25 Gy. On the other hand, PEG-AuNPs can serve as a radiation-protecting agent and enabled MCF-7 cells more resistant to the irradiation, clearly indicating the key role of surface chemistry in radiosensitization of AuNPs. More detailed studies suggested that such difference was independent of cellular uptake and its efficiency, but might be related to the ligand-induced difference in photoelectron generation and/or interactions between AuNPs and X-ray triggered reactive oxygen species (ROS). 2016-05-13 2016-07 /pmc/articles/PMC5639719/ /pubmed/29034008 http://dx.doi.org/10.1142/S1793545816420037 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article published by World Scientific Publishing Company. It is distributed under the terms of the Creative Commons Attribution 4.0 (CC-BY) License. Further distribution of this work is permitted, provided the original work is properly cited. |
spellingShingle | Article Jiang, Xingya Du, Bujie Yu, Mengxiao Jia, Xun Zheng, Jie Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles |
title | Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles |
title_full | Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles |
title_fullStr | Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles |
title_full_unstemmed | Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles |
title_short | Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles |
title_sort | surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639719/ https://www.ncbi.nlm.nih.gov/pubmed/29034008 http://dx.doi.org/10.1142/S1793545816420037 |
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