The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial

Using data form a 14-day double-blind trial with 48 smokers randomized to either N-acetylcysteine (2400 mg) or placebo, we tested the effect of N-acetylcysteine on glutamate and gamma-aminobutyric acid concentrations in the dorsal anterior cingulate cortex and on smoking cessation. Smoking related b...

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Autores principales: Schulte, MHJ, Goudriaan, AE, Kaag, AM, Kooi, DP, van den Brink, W, Wiers, RW, Schmaal, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Null Results in Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639948/
https://www.ncbi.nlm.nih.gov/pubmed/28922968
http://dx.doi.org/10.1177/0269881117730660
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author Schulte, MHJ
Goudriaan, AE
Kaag, AM
Kooi, DP
van den Brink, W
Wiers, RW
Schmaal, L
author_facet Schulte, MHJ
Goudriaan, AE
Kaag, AM
Kooi, DP
van den Brink, W
Wiers, RW
Schmaal, L
author_sort Schulte, MHJ
collection PubMed
description Using data form a 14-day double-blind trial with 48 smokers randomized to either N-acetylcysteine (2400 mg) or placebo, we tested the effect of N-acetylcysteine on glutamate and gamma-aminobutyric acid concentrations in the dorsal anterior cingulate cortex and on smoking cessation. Smoking related behaviors and neurotransmitter concentrations in the dorsal anterior cingulate cortex were assessed before and after treatment. Forty-seven non-smoking males served as baseline controls. Smokers showed higher baseline glutamate but similar gamma-aminobutyric acid concentrations than non-smokers. There were no treatment effects on dorsal anterior cingulate cortex neurotransmitter concentrations, smoking cessation, craving, or withdrawal symptoms. These results confirm glutamate disbalance in smokers, but not efficacy of N-acetylcysteine.
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spelling pubmed-56399482017-10-26 The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial Schulte, MHJ Goudriaan, AE Kaag, AM Kooi, DP van den Brink, W Wiers, RW Schmaal, L J Psychopharmacol Null Results in Brief Using data form a 14-day double-blind trial with 48 smokers randomized to either N-acetylcysteine (2400 mg) or placebo, we tested the effect of N-acetylcysteine on glutamate and gamma-aminobutyric acid concentrations in the dorsal anterior cingulate cortex and on smoking cessation. Smoking related behaviors and neurotransmitter concentrations in the dorsal anterior cingulate cortex were assessed before and after treatment. Forty-seven non-smoking males served as baseline controls. Smokers showed higher baseline glutamate but similar gamma-aminobutyric acid concentrations than non-smokers. There were no treatment effects on dorsal anterior cingulate cortex neurotransmitter concentrations, smoking cessation, craving, or withdrawal symptoms. These results confirm glutamate disbalance in smokers, but not efficacy of N-acetylcysteine. SAGE Publications 2017-09-19 2017-10 /pmc/articles/PMC5639948/ /pubmed/28922968 http://dx.doi.org/10.1177/0269881117730660 Text en © The Author(s) 2017 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Null Results in Brief
Schulte, MHJ
Goudriaan, AE
Kaag, AM
Kooi, DP
van den Brink, W
Wiers, RW
Schmaal, L
The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial
title The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial
title_full The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial
title_fullStr The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial
title_full_unstemmed The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial
title_short The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial
title_sort effect of n-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: a randomized, double-blind, placebo-controlled trial
topic Null Results in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639948/
https://www.ncbi.nlm.nih.gov/pubmed/28922968
http://dx.doi.org/10.1177/0269881117730660
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