Autophagy-monitoring and autophagy-deficient mice

Discovery of yeast autophagy-related (ATG) genes and subsequent identification of their homologs in other organisms have enabled researchers to investigate physiological functions of macroautophagy/autophagy using genetic techniques. Specific identification of autophagy-related structures is importa...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuma, Akiko, Komatsu, Masaaki, Mizushima, Noboru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640176/
https://www.ncbi.nlm.nih.gov/pubmed/28820286
http://dx.doi.org/10.1080/15548627.2017.1343770
_version_ 1783271003442380800
author Kuma, Akiko
Komatsu, Masaaki
Mizushima, Noboru
author_facet Kuma, Akiko
Komatsu, Masaaki
Mizushima, Noboru
author_sort Kuma, Akiko
collection PubMed
description Discovery of yeast autophagy-related (ATG) genes and subsequent identification of their homologs in other organisms have enabled researchers to investigate physiological functions of macroautophagy/autophagy using genetic techniques. Specific identification of autophagy-related structures is important to evaluate autophagic activity, and specific ablation of autophagy-related genes is a critical means to determine the requirements of autophagy. Here, we review currently available mouse models, particularly focusing on autophagy (and mitophagy) indicator models and systemic autophagy-related gene-knockout mouse models.
format Online
Article
Text
id pubmed-5640176
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-56401762017-10-23 Autophagy-monitoring and autophagy-deficient mice Kuma, Akiko Komatsu, Masaaki Mizushima, Noboru Autophagy Review Discovery of yeast autophagy-related (ATG) genes and subsequent identification of their homologs in other organisms have enabled researchers to investigate physiological functions of macroautophagy/autophagy using genetic techniques. Specific identification of autophagy-related structures is important to evaluate autophagic activity, and specific ablation of autophagy-related genes is a critical means to determine the requirements of autophagy. Here, we review currently available mouse models, particularly focusing on autophagy (and mitophagy) indicator models and systemic autophagy-related gene-knockout mouse models. Taylor & Francis 2017-08-18 /pmc/articles/PMC5640176/ /pubmed/28820286 http://dx.doi.org/10.1080/15548627.2017.1343770 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Kuma, Akiko
Komatsu, Masaaki
Mizushima, Noboru
Autophagy-monitoring and autophagy-deficient mice
title Autophagy-monitoring and autophagy-deficient mice
title_full Autophagy-monitoring and autophagy-deficient mice
title_fullStr Autophagy-monitoring and autophagy-deficient mice
title_full_unstemmed Autophagy-monitoring and autophagy-deficient mice
title_short Autophagy-monitoring and autophagy-deficient mice
title_sort autophagy-monitoring and autophagy-deficient mice
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640176/
https://www.ncbi.nlm.nih.gov/pubmed/28820286
http://dx.doi.org/10.1080/15548627.2017.1343770
work_keys_str_mv AT kumaakiko autophagymonitoringandautophagydeficientmice
AT komatsumasaaki autophagymonitoringandautophagydeficientmice
AT mizushimanoboru autophagymonitoringandautophagydeficientmice

Ejemplares similares