Sodium excretion is higher in patients with rheumatoid arthritis than in matched controls

OBJECTIVE: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls. METHODS: This case-control study included 24 patients with RA at diagnosis and 24 controls matc...

Descripción completa

Detalles Bibliográficos
Autores principales: Marouen, Sarah, du Cailar, Guilhem, Audo, Rachel, Lukas, Cedric, Vial, Gaelle, Tournadre, Anne, Barrat, Emmanuel, Ribstein, Jean, Combe, Bernard, Morel, Jacques, Daien, Claire I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640209/
https://www.ncbi.nlm.nih.gov/pubmed/29028829
http://dx.doi.org/10.1371/journal.pone.0186157
Descripción
Sumario:OBJECTIVE: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls. METHODS: This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion. RESULTS: Sodium excretion was greater for patients with early RA (2,849±1,350 vs. 2,182±751.7mg/day, p = 0.039) than controls. This difference remained significant after adjustment for smoking and the use of anti-hypertensive and nonsteroidal anti-inflammatory drugs (p = 0.043). Patients with radiographic erosion at the time of diagnosis had a higher sodium excretion than those without (p = 0.028). CONCLUSION: Patients with early RA showed increased sodium excretion which may have contributed to autoimmunity.

Ejemplares similares