Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

Merkel cell carcinoma (MCC) frequently contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST). While LT binds RB and inactivates its tumor suppressor function, it is less clear how ST contributes to MCC tumo...

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Detalles Bibliográficos
Autores principales: Cheng, Jingwei, Park, Donglim Esther, Berrios, Christian, White, Elizabeth A., Arora, Reety, Yoon, Rosa, Branigan, Timothy, Xiao, Tengfei, Westerling, Thomas, Federation, Alexander, Zeid, Rhamy, Strober, Benjamin, Swanson, Selene K., Florens, Laurence, Bradner, James E., Brown, Myles, Howley, Peter M., Padi, Megha, Washburn, Michael P., DeCaprio, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640240/
https://www.ncbi.nlm.nih.gov/pubmed/29028833
http://dx.doi.org/10.1371/journal.ppat.1006668

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