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Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes

Retroelements (REs) are mobile DNA sequences that multiply and spread throughout genomes by a copy-and-paste mechanism. These parasitic elements are active in diverse genomes, from yeast to humans, where they promote diversity, cause disease, and accelerate evolution. Because of their high copy numb...

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Autores principales: Levy, Orr, Knisbacher, Binyamin A., Levanon, Erez Y., Havlin, Shlomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640379/
https://www.ncbi.nlm.nih.gov/pubmed/29043294
http://dx.doi.org/10.1126/sciadv.1701256
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author Levy, Orr
Knisbacher, Binyamin A.
Levanon, Erez Y.
Havlin, Shlomo
author_facet Levy, Orr
Knisbacher, Binyamin A.
Levanon, Erez Y.
Havlin, Shlomo
author_sort Levy, Orr
collection PubMed
description Retroelements (REs) are mobile DNA sequences that multiply and spread throughout genomes by a copy-and-paste mechanism. These parasitic elements are active in diverse genomes, from yeast to humans, where they promote diversity, cause disease, and accelerate evolution. Because of their high copy number and sequence similarity, studying their activity and tracking their proliferation dynamics is a challenge. It is particularly difficult to pinpoint the few REs in a genome that are still active in the haystack of degenerate and suppressed elements. We develop a computational framework based on network theory that tracks the path of RE proliferation throughout evolution. We analyze SVA (SINE-VNTR-Alu), the youngest RE family in human genomes, to understand RE dynamics across hominids. Integrating comparative genomics and network tools enables us to track the course of SVA proliferation, identify yet unknown active communities, and detect tentative “master REs” that played key roles in SVA propagation, providing strong support for the fundamental “master gene” model of RE proliferation. The method is generic and thus can be applied to REs of any of the thousands of available genomes to identify active RE communities and master REs that were pivotal in the evolution of their host genomes.
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spelling pubmed-56403792017-10-17 Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes Levy, Orr Knisbacher, Binyamin A. Levanon, Erez Y. Havlin, Shlomo Sci Adv Research Articles Retroelements (REs) are mobile DNA sequences that multiply and spread throughout genomes by a copy-and-paste mechanism. These parasitic elements are active in diverse genomes, from yeast to humans, where they promote diversity, cause disease, and accelerate evolution. Because of their high copy number and sequence similarity, studying their activity and tracking their proliferation dynamics is a challenge. It is particularly difficult to pinpoint the few REs in a genome that are still active in the haystack of degenerate and suppressed elements. We develop a computational framework based on network theory that tracks the path of RE proliferation throughout evolution. We analyze SVA (SINE-VNTR-Alu), the youngest RE family in human genomes, to understand RE dynamics across hominids. Integrating comparative genomics and network tools enables us to track the course of SVA proliferation, identify yet unknown active communities, and detect tentative “master REs” that played key roles in SVA propagation, providing strong support for the fundamental “master gene” model of RE proliferation. The method is generic and thus can be applied to REs of any of the thousands of available genomes to identify active RE communities and master REs that were pivotal in the evolution of their host genomes. American Association for the Advancement of Science 2017-10-13 /pmc/articles/PMC5640379/ /pubmed/29043294 http://dx.doi.org/10.1126/sciadv.1701256 Text en Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Levy, Orr
Knisbacher, Binyamin A.
Levanon, Erez Y.
Havlin, Shlomo
Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes
title Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes
title_full Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes
title_fullStr Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes
title_full_unstemmed Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes
title_short Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes
title_sort integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640379/
https://www.ncbi.nlm.nih.gov/pubmed/29043294
http://dx.doi.org/10.1126/sciadv.1701256
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