Cargando…
Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response
Extensive shielding by N-glycans on the surface of the HIV envelope glycoproteins (Env) restricts B cell recognition of conserved neutralizing determinants. Elicitation of broadly neutralizing antibodies (bNAbs) in selected HIV-infected individuals reveals that Abs capable of penetrating the glycan...
Autores principales: | Dubrovskaya, Viktoriya, Guenaga, Javier, de Val, Natalia, Wilson, Richard, Feng, Yu, Movsesyan, Arlette, Karlsson Hedestam, Gunilla B., Ward, Andrew B., Wyatt, Richard T. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640423/ https://www.ncbi.nlm.nih.gov/pubmed/28902916 http://dx.doi.org/10.1371/journal.ppat.1006614 |
Ejemplares similares
-
Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
por: Dubrovskaya, Viktoriya, et al.
Publicado: (2019) -
Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice
por: Soldemo, Martina, et al.
Publicado: (2017) -
Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage
por: Yang, Lifei, et al.
Publicado: (2018) -
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates
por: Sundling, Christopher, et al.
Publicado: (2010) -
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates
por: Sundling, Christopher, et al.
Publicado: (2010)