Systematic integration of biomedical knowledge prioritizes drugs for repurposing

The ability to computationally predict whether a compound treats a disease would improve the economy and success rate of drug approval. This study describes Project Rephetio to systematically model drug efficacy based on 755 existing treatments. First, we constructed Hetionet (neo4j.het.io), an inte...

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Detalles Bibliográficos
Autores principales: Himmelstein, Daniel Scott, Lizee, Antoine, Hessler, Christine, Brueggeman, Leo, Chen, Sabrina L, Hadley, Dexter, Green, Ari, Khankhanian, Pouya, Baranzini, Sergio E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640425/
https://www.ncbi.nlm.nih.gov/pubmed/28936969
http://dx.doi.org/10.7554/eLife.26726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640425/
https://www.ncbi.nlm.nih.gov/pubmed/28936969
http://dx.doi.org/10.7554/eLife.26726

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