Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea

Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea; however, its biosynthetic cluster lacks a regulatory gene, limiting the yield enhancement via regulation engineering of S. erythraea. Herein, six TetR family transcriptional regulators (TFRs) belonging to three genom...

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Detalles Bibliográficos
Autores principales: Wu, Hang, Wang, Yansheng, Yuan, Li, Mao, Yongrong, Wang, Weiwei, Zhu, Lin, Wu, Panpan, Fu, Chengzhang, Müller, Rolf, Weaver, David T., Zhang, Lixin, Zhang, Buchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640589/
https://www.ncbi.nlm.nih.gov/pubmed/29062926
http://dx.doi.org/10.1016/j.synbio.2016.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640589/
https://www.ncbi.nlm.nih.gov/pubmed/29062926
http://dx.doi.org/10.1016/j.synbio.2016.01.004

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