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New insights into the degradation mechanism of metal-organic frameworks drug carriers
A versatile method based on Raman microscopy was developed to follow the degradation of iron carboxylate Metal Organic Framework (MOF) nano- or micro-particles in simulated body fluid (phosphate buffer). The analysis of both the morphology and chemical composition of individual particles, including...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640595/ https://www.ncbi.nlm.nih.gov/pubmed/29030570 http://dx.doi.org/10.1038/s41598-017-13323-1 |
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author | Li, X. Lachmanski, L. Safi, S. Sene, S. Serre, C. Grenèche, J. M. Zhang, J. Gref, R. |
author_facet | Li, X. Lachmanski, L. Safi, S. Sene, S. Serre, C. Grenèche, J. M. Zhang, J. Gref, R. |
author_sort | Li, X. |
collection | PubMed |
description | A versatile method based on Raman microscopy was developed to follow the degradation of iron carboxylate Metal Organic Framework (MOF) nano- or micro-particles in simulated body fluid (phosphate buffer). The analysis of both the morphology and chemical composition of individual particles, including observation at different regions on the same particle, evidenced the formation of a sharp erosion front during particle degradation. Interestingly, this front separated an intact non eroded crystalline core from an amorphous shell made of an inorganic network. According to Mössbauer spectrometry investigations, the shell consists essentially of iron phosphates. Noteworthy, neither drug loading nor surface modification affected the integrity of the tridimensional MOF network. These findings could be of interest in the further development of next generations of MOF drug carriers. |
format | Online Article Text |
id | pubmed-5640595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56405952017-10-18 New insights into the degradation mechanism of metal-organic frameworks drug carriers Li, X. Lachmanski, L. Safi, S. Sene, S. Serre, C. Grenèche, J. M. Zhang, J. Gref, R. Sci Rep Article A versatile method based on Raman microscopy was developed to follow the degradation of iron carboxylate Metal Organic Framework (MOF) nano- or micro-particles in simulated body fluid (phosphate buffer). The analysis of both the morphology and chemical composition of individual particles, including observation at different regions on the same particle, evidenced the formation of a sharp erosion front during particle degradation. Interestingly, this front separated an intact non eroded crystalline core from an amorphous shell made of an inorganic network. According to Mössbauer spectrometry investigations, the shell consists essentially of iron phosphates. Noteworthy, neither drug loading nor surface modification affected the integrity of the tridimensional MOF network. These findings could be of interest in the further development of next generations of MOF drug carriers. Nature Publishing Group UK 2017-10-13 /pmc/articles/PMC5640595/ /pubmed/29030570 http://dx.doi.org/10.1038/s41598-017-13323-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Li, X. Lachmanski, L. Safi, S. Sene, S. Serre, C. Grenèche, J. M. Zhang, J. Gref, R. New insights into the degradation mechanism of metal-organic frameworks drug carriers |
title | New insights into the degradation mechanism of metal-organic frameworks drug carriers |
title_full | New insights into the degradation mechanism of metal-organic frameworks drug carriers |
title_fullStr | New insights into the degradation mechanism of metal-organic frameworks drug carriers |
title_full_unstemmed | New insights into the degradation mechanism of metal-organic frameworks drug carriers |
title_short | New insights into the degradation mechanism of metal-organic frameworks drug carriers |
title_sort | new insights into the degradation mechanism of metal-organic frameworks drug carriers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640595/ https://www.ncbi.nlm.nih.gov/pubmed/29030570 http://dx.doi.org/10.1038/s41598-017-13323-1 |
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