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Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras

Yeast and cancer cells share the unusual characteristic of favoring fermentation of sugar over respiration. We now reveal an evolutionary conserved mechanism linking fermentation to activation of Ras, a major regulator of cell proliferation in yeast and mammalian cells, and prime proto-oncogene prod...

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Detalles Bibliográficos
Autores principales:	Peeters, Ken, Van Leemputte, Frederik, Fischer, Baptiste, Bonini, Beatriz M., Quezada, Hector, Tsytlonok, Maksym, Haesen, Dorien, Vanthienen, Ward, Bernardes, Nuno, Gonzalez-Blas, Carmen Bravo, Janssens, Veerle, Tompa, Peter, Versées, Wim, Thevelein, Johan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640605/ https://www.ncbi.nlm.nih.gov/pubmed/29030545 http://dx.doi.org/10.1038/s41467-017-01019-z

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