A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction

Loss of protein and organelle quality control secondary to reduced autophagy is a hallmark of aging. However, the physiologic and molecular regulation of autophagy in long-lived organisms remains incompletely understood. Here we show that the Kruppel-like family of transcription factors are importan...

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Detalles Bibliográficos
Autores principales: Hsieh, Paishiun N., Zhou, Guangjin, Yuan, Yiyuan, Zhang, Rongli, Prosdocimo, Domenick A., Sangwung, Panjamaporn, Borton, Anna H., Boriushkin, Evgenii, Hamik, Anne, Fujioka, Hisashi, Fealy, Ciaran E., Kirwan, John P., Peters, Maureen, Lu, Yuan, Liao, Xudong, Ramírez-Bergeron, Diana, Feng, Zhaoyang, Jain, Mukesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640649/
https://www.ncbi.nlm.nih.gov/pubmed/29030550
http://dx.doi.org/10.1038/s41467-017-00899-5

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