NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation (Nt-acetylation) of histone H4 known to be involved in cell growth. Here we report that NatD promotes the migratory and invasive capabilities of lung cancer cells in vitro and in vivo. Depletion of NatD suppresses the epithelial-to-mes...

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Detalles Bibliográficos
Autores principales: Ju, Junyi, Chen, Aiping, Deng, Yexuan, Liu, Ming, Wang, Ying, Wang, Yadong, Nie, Min, Wang, Chao, Ding, Hong, Yao, Bing, Gui, Tao, Li, Xinyu, Xu, Zhen, Ma, Chi, Song, Yong, Kvansakul, Marc, Zen, Ke, Zhang, Chen-Yu, Luo, Cheng, Fang, Ming, Huang, David C. S., Allis, C. David, Tan, Renxiang, Zeng, Changjiang Kathy, Wei, Jiwu, Zhao, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640650/
https://www.ncbi.nlm.nih.gov/pubmed/29030587
http://dx.doi.org/10.1038/s41467-017-00988-5

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