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Maternal consumption of fish oil programs reduced adiposity in broiler chicks

Maternal intake of eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (22:6 n-3) has been associated with reduced adiposity in children, suggesting the possibility to program adipose development through dietary fatty acids before birth. This study determined if enriching the maternal die...

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Autores principales: Beckford, Ronique C., Howard, Sarah J., Das, Suchita, Farmer, Abigail T., Campagna, Shawn R., Yu, Jiali, Hettich, Robert L., Wilson, Jeanna L., Voy, Brynn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640664/
https://www.ncbi.nlm.nih.gov/pubmed/29030616
http://dx.doi.org/10.1038/s41598-017-13519-5
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author Beckford, Ronique C.
Howard, Sarah J.
Das, Suchita
Farmer, Abigail T.
Campagna, Shawn R.
Yu, Jiali
Hettich, Robert L.
Wilson, Jeanna L.
Voy, Brynn H.
author_facet Beckford, Ronique C.
Howard, Sarah J.
Das, Suchita
Farmer, Abigail T.
Campagna, Shawn R.
Yu, Jiali
Hettich, Robert L.
Wilson, Jeanna L.
Voy, Brynn H.
author_sort Beckford, Ronique C.
collection PubMed
description Maternal intake of eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (22:6 n-3) has been associated with reduced adiposity in children, suggesting the possibility to program adipose development through dietary fatty acids before birth. This study determined if enriching the maternal diet in fish oil, the primary source of EPA and DHA, affected adipose development in offspring. Broiler chickens were used because they are obesity-prone, and because fatty acids provided to the embryo can be manipulated through the hen diet. Hens were fed diets supplemented (2.8% wt:wt) with corn oil (CO; n-6) or fish oil (FO; n-3) for 28 d. Chicks from both maternal diet groups were fed the same diet after hatch. Maternal FO consumption enriched chick adipose tissue in EPA and DHA and reduced adiposity by promoting more, but smaller, adipocytes. This adipocyte profile was paralleled by lower expression of the adipogenic regulator PPARG and its co-activator PPARGC1B, and elevated expression of LPL. Proteomics identified 95 differentially abundant proteins between FO and CO adipose tissue, including components of glucose metabolism, lipid droplet trafficking, and cytoskeletal organization. These results demonstrate that the maternal dietary fatty acid profile programs offspring adipose development.
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spelling pubmed-56406642017-10-18 Maternal consumption of fish oil programs reduced adiposity in broiler chicks Beckford, Ronique C. Howard, Sarah J. Das, Suchita Farmer, Abigail T. Campagna, Shawn R. Yu, Jiali Hettich, Robert L. Wilson, Jeanna L. Voy, Brynn H. Sci Rep Article Maternal intake of eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (22:6 n-3) has been associated with reduced adiposity in children, suggesting the possibility to program adipose development through dietary fatty acids before birth. This study determined if enriching the maternal diet in fish oil, the primary source of EPA and DHA, affected adipose development in offspring. Broiler chickens were used because they are obesity-prone, and because fatty acids provided to the embryo can be manipulated through the hen diet. Hens were fed diets supplemented (2.8% wt:wt) with corn oil (CO; n-6) or fish oil (FO; n-3) for 28 d. Chicks from both maternal diet groups were fed the same diet after hatch. Maternal FO consumption enriched chick adipose tissue in EPA and DHA and reduced adiposity by promoting more, but smaller, adipocytes. This adipocyte profile was paralleled by lower expression of the adipogenic regulator PPARG and its co-activator PPARGC1B, and elevated expression of LPL. Proteomics identified 95 differentially abundant proteins between FO and CO adipose tissue, including components of glucose metabolism, lipid droplet trafficking, and cytoskeletal organization. These results demonstrate that the maternal dietary fatty acid profile programs offspring adipose development. Nature Publishing Group UK 2017-10-13 /pmc/articles/PMC5640664/ /pubmed/29030616 http://dx.doi.org/10.1038/s41598-017-13519-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Beckford, Ronique C.
Howard, Sarah J.
Das, Suchita
Farmer, Abigail T.
Campagna, Shawn R.
Yu, Jiali
Hettich, Robert L.
Wilson, Jeanna L.
Voy, Brynn H.
Maternal consumption of fish oil programs reduced adiposity in broiler chicks
title Maternal consumption of fish oil programs reduced adiposity in broiler chicks
title_full Maternal consumption of fish oil programs reduced adiposity in broiler chicks
title_fullStr Maternal consumption of fish oil programs reduced adiposity in broiler chicks
title_full_unstemmed Maternal consumption of fish oil programs reduced adiposity in broiler chicks
title_short Maternal consumption of fish oil programs reduced adiposity in broiler chicks
title_sort maternal consumption of fish oil programs reduced adiposity in broiler chicks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640664/
https://www.ncbi.nlm.nih.gov/pubmed/29030616
http://dx.doi.org/10.1038/s41598-017-13519-5
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