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Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population

Single-nucleotide polymorphisms (SNPs) in the ETS1 gene are associated with several auto-inflammatory diseases. In this study, we determined whether ETS1 gene polymorphisms confer susceptibility to idiopathic inflammatory myopathies (IIMs) in a northern Chinese Han population. DNA samples were colle...

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Autores principales: Chen, Si, Wen, Xiaoting, Li, Liubing, Li, Jing, Li, Yuan, Wang, Qian, Yuan, Hui, Zhang, Fengchun, Li, Yongzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640673/
https://www.ncbi.nlm.nih.gov/pubmed/29030598
http://dx.doi.org/10.1038/s41598-017-13385-1
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author Chen, Si
Wen, Xiaoting
Li, Liubing
Li, Jing
Li, Yuan
Wang, Qian
Yuan, Hui
Zhang, Fengchun
Li, Yongzhe
author_facet Chen, Si
Wen, Xiaoting
Li, Liubing
Li, Jing
Li, Yuan
Wang, Qian
Yuan, Hui
Zhang, Fengchun
Li, Yongzhe
author_sort Chen, Si
collection PubMed
description Single-nucleotide polymorphisms (SNPs) in the ETS1 gene are associated with several auto-inflammatory diseases. In this study, we determined whether ETS1 gene polymorphisms confer susceptibility to idiopathic inflammatory myopathies (IIMs) in a northern Chinese Han population. DNA samples were collected from 1017 IIM patients: 363 PM cases and 654 DM cases. The results were compared with those of 1280 healthy controls. Five SNPs in the ETS1 region (rs7117932, rs6590330, rs4937362, rs10893845 and rs1128334) were assessed and genotyped using the Sequenom platform. Our data indicated that the rs7117932 alleles and genotypes are associated with DM and IIMs (P (c) = 6.0 × 10(−3) and P (c) = 0.029; P (c) = 0.013 and P (c) = 0.019, respectively). We found a significantly greater percentage of DM and IIM patients with an A allele of rs6590330 than that in the control population (P (c) = 0.033 and P (c) = 0.013). Additionally, the rs6590330 genotype was associated with IIMs (P (c) = 0.020). The percentages of rs7117932 and rs6590330 SNPs were significantly greater in DM and IIM patients with interstitial lung disease (ILD) (all P (c) < 0.05). This is the first study to reveal that ETS1 polymorphisms are associated with IIMs alone and IIMs with ILD in a northern Chinese Han population.
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spelling pubmed-56406732017-10-18 Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population Chen, Si Wen, Xiaoting Li, Liubing Li, Jing Li, Yuan Wang, Qian Yuan, Hui Zhang, Fengchun Li, Yongzhe Sci Rep Article Single-nucleotide polymorphisms (SNPs) in the ETS1 gene are associated with several auto-inflammatory diseases. In this study, we determined whether ETS1 gene polymorphisms confer susceptibility to idiopathic inflammatory myopathies (IIMs) in a northern Chinese Han population. DNA samples were collected from 1017 IIM patients: 363 PM cases and 654 DM cases. The results were compared with those of 1280 healthy controls. Five SNPs in the ETS1 region (rs7117932, rs6590330, rs4937362, rs10893845 and rs1128334) were assessed and genotyped using the Sequenom platform. Our data indicated that the rs7117932 alleles and genotypes are associated with DM and IIMs (P (c) = 6.0 × 10(−3) and P (c) = 0.029; P (c) = 0.013 and P (c) = 0.019, respectively). We found a significantly greater percentage of DM and IIM patients with an A allele of rs6590330 than that in the control population (P (c) = 0.033 and P (c) = 0.013). Additionally, the rs6590330 genotype was associated with IIMs (P (c) = 0.020). The percentages of rs7117932 and rs6590330 SNPs were significantly greater in DM and IIM patients with interstitial lung disease (ILD) (all P (c) < 0.05). This is the first study to reveal that ETS1 polymorphisms are associated with IIMs alone and IIMs with ILD in a northern Chinese Han population. Nature Publishing Group UK 2017-10-13 /pmc/articles/PMC5640673/ /pubmed/29030598 http://dx.doi.org/10.1038/s41598-017-13385-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Si
Wen, Xiaoting
Li, Liubing
Li, Jing
Li, Yuan
Wang, Qian
Yuan, Hui
Zhang, Fengchun
Li, Yongzhe
Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population
title Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population
title_full Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population
title_fullStr Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population
title_full_unstemmed Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population
title_short Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population
title_sort single nucleotide polymorphisms in the ets1 gene are associated with idiopathic inflammatory myopathies in a northern chinese han population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640673/
https://www.ncbi.nlm.nih.gov/pubmed/29030598
http://dx.doi.org/10.1038/s41598-017-13385-1
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