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Preprocessing of (18)F-DMFP-PET Data Based on Hidden Markov Random Fields and the Gaussian Distribution

(18)F-DMFP-PET is an emerging neuroimaging modality used to diagnose Parkinson's disease (PD) that allows us to examine postsynaptic dopamine D(2/3) receptors. Like other neuroimaging modalities used for PD diagnosis, most of the total intensity of (18)F-DMFP-PET images is concentrated in the s...

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Detalles Bibliográficos
Autores principales: Segovia, Fermín, Górriz, Juan M., Ramírez, Javier, Martínez-Murcia, Francisco J., Salas-Gonzalez, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640782/
https://www.ncbi.nlm.nih.gov/pubmed/29062277
http://dx.doi.org/10.3389/fnagi.2017.00326
Descripción
Sumario:(18)F-DMFP-PET is an emerging neuroimaging modality used to diagnose Parkinson's disease (PD) that allows us to examine postsynaptic dopamine D(2/3) receptors. Like other neuroimaging modalities used for PD diagnosis, most of the total intensity of (18)F-DMFP-PET images is concentrated in the striatum. However, other regions can also be useful for diagnostic purposes. An appropriate delimitation of the regions of interest contained in (18)F-DMFP-PET data is crucial to improve the automatic diagnosis of PD. In this manuscript we propose a novel methodology to preprocess (18)F-DMFP-PET data that improves the accuracy of computer aided diagnosis systems for PD. First, the data were segmented using an algorithm based on Hidden Markov Random Field. As a result, each neuroimage was divided into 4 maps according to the intensity and the neighborhood of the voxels. The maps were then individually normalized so that the shape of their histograms could be modeled by a Gaussian distribution with equal parameters for all the neuroimages. This approach was evaluated using a dataset with neuroimaging data from 87 parkinsonian patients. After these preprocessing steps, a Support Vector Machine classifier was used to separate idiopathic and non-idiopathic PD. Data preprocessed by the proposed method provided higher accuracy results than the ones preprocessed with previous approaches.