Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib

IL-6 is a central mediator of the immediate induction of hepatic acute phase proteins (APP) in the liver during infection and after injury, but increased IL-6 activity has been associated with multiple pathological conditions. In hepatocytes, IL-6 activates JAK1-STAT3 signaling that induces the nega...

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Detalles Bibliográficos
Autores principales: Sobotta, Svantje, Raue, Andreas, Huang, Xiaoyun, Vanlier, Joep, Jünger, Anja, Bohl, Sebastian, Albrecht, Ute, Hahnel, Maximilian J., Wolf, Stephanie, Mueller, Nikola S., D'Alessandro, Lorenza A., Mueller-Bohl, Stephanie, Boehm, Martin E., Lucarelli, Philippe, Bonefas, Sandra, Damm, Georg, Seehofer, Daniel, Lehmann, Wolf D., Rose-John, Stefan, van der Hoeven, Frank, Gretz, Norbert, Theis, Fabian J., Ehlting, Christian, Bode, Johannes G., Timmer, Jens, Schilling, Marcel, Klingmüller, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640784/
https://www.ncbi.nlm.nih.gov/pubmed/29062282
http://dx.doi.org/10.3389/fphys.2017.00775

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