Evaluation of VNTR polymorphisms of dopamine transporter gene and the risk of bipolar disorder in Zahedan, southeast Iran

The exact role of dopamine transporter gene (DAT1) in the pathogenesis of bipolar disorder type 1 (BD) is not understood. In the present study, we aimed to evaluate the possible association between 30, 40 and 63 bp variable number tandem repeat (VNTR) polymorphisms of DAT1 gene and the risk of type...

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Autores principales: Shakiba, Mansour, Hashemi, Mohammad, Mahdar, Salah, Rahbari, Zahra, Bahari, Gholamreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640894/
https://www.ncbi.nlm.nih.gov/pubmed/29071281
http://dx.doi.org/10.22099/mbrc.2017.25056.1261
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author Shakiba, Mansour
Hashemi, Mohammad
Mahdar, Salah
Rahbari, Zahra
Bahari, Gholamreza
author_facet Shakiba, Mansour
Hashemi, Mohammad
Mahdar, Salah
Rahbari, Zahra
Bahari, Gholamreza
author_sort Shakiba, Mansour
collection PubMed
description The exact role of dopamine transporter gene (DAT1) in the pathogenesis of bipolar disorder type 1 (BD) is not understood. In the present study, we aimed to evaluate the possible association between 30, 40 and 63 bp variable number tandem repeat (VNTR) polymorphisms of DAT1 gene and the risk of type 1 (BD) in a sample of Iranian population. This case-control study was performed on 152 BD patients and 153 psychiatrically healthy subjects. Genotyping of the variant was done by polymerase chain reaction method. Totally, the findings did not support an association between DAT1 VNTR polymorphisms and the risk of BD in a sample of southeast Iranian population.
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spelling pubmed-56408942017-10-25 Evaluation of VNTR polymorphisms of dopamine transporter gene and the risk of bipolar disorder in Zahedan, southeast Iran Shakiba, Mansour Hashemi, Mohammad Mahdar, Salah Rahbari, Zahra Bahari, Gholamreza Mol Biol Res Commun Short Communication The exact role of dopamine transporter gene (DAT1) in the pathogenesis of bipolar disorder type 1 (BD) is not understood. In the present study, we aimed to evaluate the possible association between 30, 40 and 63 bp variable number tandem repeat (VNTR) polymorphisms of DAT1 gene and the risk of type 1 (BD) in a sample of Iranian population. This case-control study was performed on 152 BD patients and 153 psychiatrically healthy subjects. Genotyping of the variant was done by polymerase chain reaction method. Totally, the findings did not support an association between DAT1 VNTR polymorphisms and the risk of BD in a sample of southeast Iranian population. Shiraz University 2017-09 /pmc/articles/PMC5640894/ /pubmed/29071281 http://dx.doi.org/10.22099/mbrc.2017.25056.1261 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Shakiba, Mansour
Hashemi, Mohammad
Mahdar, Salah
Rahbari, Zahra
Bahari, Gholamreza
Evaluation of VNTR polymorphisms of dopamine transporter gene and the risk of bipolar disorder in Zahedan, southeast Iran
title Evaluation of VNTR polymorphisms of dopamine transporter gene and the risk of bipolar disorder in Zahedan, southeast Iran
title_full Evaluation of VNTR polymorphisms of dopamine transporter gene and the risk of bipolar disorder in Zahedan, southeast Iran
title_fullStr Evaluation of VNTR polymorphisms of dopamine transporter gene and the risk of bipolar disorder in Zahedan, southeast Iran
title_full_unstemmed Evaluation of VNTR polymorphisms of dopamine transporter gene and the risk of bipolar disorder in Zahedan, southeast Iran
title_short Evaluation of VNTR polymorphisms of dopamine transporter gene and the risk of bipolar disorder in Zahedan, southeast Iran
title_sort evaluation of vntr polymorphisms of dopamine transporter gene and the risk of bipolar disorder in zahedan, southeast iran
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640894/
https://www.ncbi.nlm.nih.gov/pubmed/29071281
http://dx.doi.org/10.22099/mbrc.2017.25056.1261
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