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Occurrence and reproductive roles of hormones in seminal plasma

Only 2–5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling the...

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Autores principales: Vitku, Jana, Kolatorova, Lucie, Hampl, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640966/
https://www.ncbi.nlm.nih.gov/pubmed/29046808
http://dx.doi.org/10.1186/s12610-017-0062-y
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author Vitku, Jana
Kolatorova, Lucie
Hampl, Richard
author_facet Vitku, Jana
Kolatorova, Lucie
Hampl, Richard
author_sort Vitku, Jana
collection PubMed
description Only 2–5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided. Their participation in fertilization is discussed including their indispensable role in ovum fertilization. The origin of individual hormones found in seminal plasma is discussed, along with differences in the concentrations in seminal plasma and blood plasma. A part of review is devoted to methods of measurement, emphasising particular instances in which they differ from measurement in blood plasma. These methods include separation techniques, overcoming the matrix effect and current ways for end-point measurement, focusing on so called hyphenated techniques as a combination of chromatographic separation and mass spectrometry. Finally, the informative value of their determination as markers of male fertility disorders (impaired spermatogenesis, abnormal sperm parameters, varicocele) is discussed, along with instances where measuring their levels in seminal plasma is preferable to measurement of levels in blood plasma.
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spelling pubmed-56409662017-10-18 Occurrence and reproductive roles of hormones in seminal plasma Vitku, Jana Kolatorova, Lucie Hampl, Richard Basic Clin Androl Review Article Only 2–5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided. Their participation in fertilization is discussed including their indispensable role in ovum fertilization. The origin of individual hormones found in seminal plasma is discussed, along with differences in the concentrations in seminal plasma and blood plasma. A part of review is devoted to methods of measurement, emphasising particular instances in which they differ from measurement in blood plasma. These methods include separation techniques, overcoming the matrix effect and current ways for end-point measurement, focusing on so called hyphenated techniques as a combination of chromatographic separation and mass spectrometry. Finally, the informative value of their determination as markers of male fertility disorders (impaired spermatogenesis, abnormal sperm parameters, varicocele) is discussed, along with instances where measuring their levels in seminal plasma is preferable to measurement of levels in blood plasma. BioMed Central 2017-09-08 /pmc/articles/PMC5640966/ /pubmed/29046808 http://dx.doi.org/10.1186/s12610-017-0062-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review Article
Vitku, Jana
Kolatorova, Lucie
Hampl, Richard
Occurrence and reproductive roles of hormones in seminal plasma
title Occurrence and reproductive roles of hormones in seminal plasma
title_full Occurrence and reproductive roles of hormones in seminal plasma
title_fullStr Occurrence and reproductive roles of hormones in seminal plasma
title_full_unstemmed Occurrence and reproductive roles of hormones in seminal plasma
title_short Occurrence and reproductive roles of hormones in seminal plasma
title_sort occurrence and reproductive roles of hormones in seminal plasma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640966/
https://www.ncbi.nlm.nih.gov/pubmed/29046808
http://dx.doi.org/10.1186/s12610-017-0062-y
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