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A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china
BACKGROUND: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients. METHODS: This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) re...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641082/ https://www.ncbi.nlm.nih.gov/pubmed/29069739 http://dx.doi.org/10.18632/oncotarget.17599 |
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author | Fan, Jin-Hu Zhang, Yu-Qing Shi, Su-Sheng Chen, Yuan-Jia Yuan, Xing-Hua Jiang, Li-Ming Wang, Shao-Ming Ma, Li He, Yu-Tong Feng, Chang-Yan Sun, Xi-Bin Liu, Qing Deloso, Katrina Chi, Yihebali Qiao, You-Lin |
author_facet | Fan, Jin-Hu Zhang, Yu-Qing Shi, Su-Sheng Chen, Yuan-Jia Yuan, Xing-Hua Jiang, Li-Ming Wang, Shao-Ming Ma, Li He, Yu-Tong Feng, Chang-Yan Sun, Xi-Bin Liu, Qing Deloso, Katrina Chi, Yihebali Qiao, You-Lin |
author_sort | Fan, Jin-Hu |
collection | PubMed |
description | BACKGROUND: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients. METHODS: This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients’ information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included. The primary GEP-NEN sites were measured and the epidemiological and clinical information of each tumor site were compared. RESULTS: The most common primary sites for GEP-NEN were the pancreas (31.5%) and rectum (29.6%), followed by the cardia (11.6%) and body (15.4%) of stomach. Small intestinal and colonic NENs took up a relatively small proportion of all patients. Pancreatic and rectal NENs, rather than cardiac and gastric body NENs, tended to be found in younger (P<0.001), female (P<0.001), urban (P<0.001) residents with a higher education level (P=0.032) and were also diagnosed at earlier stage (P<0.001) and lower grade (P<0.001). Surgery remained the primary treatment method in all groups. CONCLUSIONS: More studies on the commonality and heterogeneity of GEP-NENs are warranted to improve diagnosis efficiencies and treatment outcomes. |
format | Online Article Text |
id | pubmed-5641082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56410822017-10-24 A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china Fan, Jin-Hu Zhang, Yu-Qing Shi, Su-Sheng Chen, Yuan-Jia Yuan, Xing-Hua Jiang, Li-Ming Wang, Shao-Ming Ma, Li He, Yu-Tong Feng, Chang-Yan Sun, Xi-Bin Liu, Qing Deloso, Katrina Chi, Yihebali Qiao, You-Lin Oncotarget Research Paper BACKGROUND: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients. METHODS: This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients’ information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included. The primary GEP-NEN sites were measured and the epidemiological and clinical information of each tumor site were compared. RESULTS: The most common primary sites for GEP-NEN were the pancreas (31.5%) and rectum (29.6%), followed by the cardia (11.6%) and body (15.4%) of stomach. Small intestinal and colonic NENs took up a relatively small proportion of all patients. Pancreatic and rectal NENs, rather than cardiac and gastric body NENs, tended to be found in younger (P<0.001), female (P<0.001), urban (P<0.001) residents with a higher education level (P=0.032) and were also diagnosed at earlier stage (P<0.001) and lower grade (P<0.001). Surgery remained the primary treatment method in all groups. CONCLUSIONS: More studies on the commonality and heterogeneity of GEP-NENs are warranted to improve diagnosis efficiencies and treatment outcomes. Impact Journals LLC 2017-05-03 /pmc/articles/PMC5641082/ /pubmed/29069739 http://dx.doi.org/10.18632/oncotarget.17599 Text en Copyright: © 2017 Fan et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Fan, Jin-Hu Zhang, Yu-Qing Shi, Su-Sheng Chen, Yuan-Jia Yuan, Xing-Hua Jiang, Li-Ming Wang, Shao-Ming Ma, Li He, Yu-Tong Feng, Chang-Yan Sun, Xi-Bin Liu, Qing Deloso, Katrina Chi, Yihebali Qiao, You-Lin A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china |
title | A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china |
title_full | A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china |
title_fullStr | A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china |
title_full_unstemmed | A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china |
title_short | A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china |
title_sort | nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641082/ https://www.ncbi.nlm.nih.gov/pubmed/29069739 http://dx.doi.org/10.18632/oncotarget.17599 |
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