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The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling

Sirtuin 6 (SIRT6) is an important modulator of cardiovascular functions in health and diseases. However, the exact role of SIRT6 in heart disease is poorly defined. We hypothesized that SIRT6 is a negative regulator of angiotensin II (Ang II)-mediated myocardial remodeling, fibrosis and injury. The...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhen-Zhou, Cheng, Yu-Wen, Jin, Hai-Yan, Chang, Qing, Shang, Qian-Hui, Xu, Ying-Le, Chen, Lin-Xi, Xu, Ran, Song, Bei, Zhong, Jiu-Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641131/ https://www.ncbi.nlm.nih.gov/pubmed/29069788 http://dx.doi.org/10.18632/oncotarget.20305

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