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Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum

A neuron sprouts an axon, and its branches to innervate many target neurons that are divergent in their functions. In order to efficiently regulate the diversified cells, the axon branches should differentiate functionally to be compatible with their target neurons, i.e., a function compatibility be...

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Autores principales: Yang, Zhilai, Chen, Na, Ge, Rongjing, Qian, Hao, Wang, Jin-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641142/
https://www.ncbi.nlm.nih.gov/pubmed/29069799
http://dx.doi.org/10.18632/oncotarget.19770
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author Yang, Zhilai
Chen, Na
Ge, Rongjing
Qian, Hao
Wang, Jin-Hui
author_facet Yang, Zhilai
Chen, Na
Ge, Rongjing
Qian, Hao
Wang, Jin-Hui
author_sort Yang, Zhilai
collection PubMed
description A neuron sprouts an axon, and its branches to innervate many target neurons that are divergent in their functions. In order to efficiently regulate the diversified cells, the axon branches should differentiate functionally to be compatible with their target neurons, i.e., a function compatibility between presynaptic and postsynaptic partners. We have examined this hypothesis by using electrophysiological method in the cerebellum, in which the main axon of Purkinje cell projected to deep nucleus cells and the recurrent axons innervated the adjacent Purkinje cells. The fidelity of spike propagation is superior in the recurrent branches than the main axon. The capabilities of encoding spikes and processing GABAergic inputs are advanced in Purkinje cells versus deep nucleus cells. The functional differences among Purkinje's axonal branches and their postsynaptic neurons are preset by the variable dynamics of their voltage-gated sodium channels. In addition, activity strengths between presynaptic and postsynaptic partners are proportionally correlated, i.e., active axonal branches innervate active target neurons, or vice versa. The physiological impact of the functional compatibility is to make the neurons in their circuits to be activated appropriately. In conclusion, each cerebellar Purkinje cell sprouts the differentiated axon branches to be compatible with the diversified target cells in their functions, in order to construct the homeostatic and efficient units for their coordinated activity in neural circuits.
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spelling pubmed-56411422017-10-24 Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum Yang, Zhilai Chen, Na Ge, Rongjing Qian, Hao Wang, Jin-Hui Oncotarget Research Paper A neuron sprouts an axon, and its branches to innervate many target neurons that are divergent in their functions. In order to efficiently regulate the diversified cells, the axon branches should differentiate functionally to be compatible with their target neurons, i.e., a function compatibility between presynaptic and postsynaptic partners. We have examined this hypothesis by using electrophysiological method in the cerebellum, in which the main axon of Purkinje cell projected to deep nucleus cells and the recurrent axons innervated the adjacent Purkinje cells. The fidelity of spike propagation is superior in the recurrent branches than the main axon. The capabilities of encoding spikes and processing GABAergic inputs are advanced in Purkinje cells versus deep nucleus cells. The functional differences among Purkinje's axonal branches and their postsynaptic neurons are preset by the variable dynamics of their voltage-gated sodium channels. In addition, activity strengths between presynaptic and postsynaptic partners are proportionally correlated, i.e., active axonal branches innervate active target neurons, or vice versa. The physiological impact of the functional compatibility is to make the neurons in their circuits to be activated appropriately. In conclusion, each cerebellar Purkinje cell sprouts the differentiated axon branches to be compatible with the diversified target cells in their functions, in order to construct the homeostatic and efficient units for their coordinated activity in neural circuits. Impact Journals LLC 2017-08-01 /pmc/articles/PMC5641142/ /pubmed/29069799 http://dx.doi.org/10.18632/oncotarget.19770 Text en Copyright: © 2017 Yang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Yang, Zhilai
Chen, Na
Ge, Rongjing
Qian, Hao
Wang, Jin-Hui
Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum
title Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum
title_full Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum
title_fullStr Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum
title_full_unstemmed Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum
title_short Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum
title_sort functional compatibility between purkinje cell axon branches and their target neurons in the cerebellum
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641142/
https://www.ncbi.nlm.nih.gov/pubmed/29069799
http://dx.doi.org/10.18632/oncotarget.19770
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