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Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression

Major depression has various types of symptoms and disease courses with inconsistent response to monoamine-related antidepressants. Thus, monoamine theory may not be the only pathophysiologic pathway relevant to depression. Recently, it has been suggested that regulatory T cell (Treg) is associated...

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Autores principales: Park, Hyun-Sun, Han, Arum, Yeo, Hye-Lim, Park, Min-Jung, You, Min-Jung, Choi, Hyun Jin, Hong, Chang-Won, Lee, Sang-Hyuk, Kim, Seung Hyun, Kim, Borah, Kwon, Min-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641150/
https://www.ncbi.nlm.nih.gov/pubmed/29069807
http://dx.doi.org/10.18632/oncotarget.19879
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author Park, Hyun-Sun
Han, Arum
Yeo, Hye-Lim
Park, Min-Jung
You, Min-Jung
Choi, Hyun Jin
Hong, Chang-Won
Lee, Sang-Hyuk
Kim, Seung Hyun
Kim, Borah
Kwon, Min-Soo
author_facet Park, Hyun-Sun
Han, Arum
Yeo, Hye-Lim
Park, Min-Jung
You, Min-Jung
Choi, Hyun Jin
Hong, Chang-Won
Lee, Sang-Hyuk
Kim, Seung Hyun
Kim, Borah
Kwon, Min-Soo
author_sort Park, Hyun-Sun
collection PubMed
description Major depression has various types of symptoms and disease courses with inconsistent response to monoamine-related antidepressants. Thus, monoamine theory may not be the only pathophysiologic pathway relevant to depression. Recently, it has been suggested that regulatory T cell (Treg) is associated with depression. Based on our previous study that showed decreased regulatory T cell (Treg) population following chronic high-dose captopril (CHC, 40 mg/kg/day * 21 days) administration, we examined whether CHC alone can induce depressive-like behaviors in mice even without stressful stimuli. In this study, we found that CHC induced depressive-like behaviors in tail suspension test (TST) and forced swimming test (FST) without systemic illness, while it did not induce anhedonic behavior, anxiety-like behaviors, or sociality-related behavior. The depressive-like behaviors were rescued by either CHC washout or antidepressant. CHC caused reduction in foxp3 and gata3 mRNA expression in the lymph nodes with elevation in plasma IL-1β and IL-6. Interestingly, CHC increased serum angiotensin II level. In the hippocampus, CHC increased TNF-α and IL-6 mRNA expression with microglia activation while reduced glucocorticoid receptor expression. However, CHC did not affect to hippocampal kynurenine pathway, serotonin level, hypothalamic corticotropin-releasing hormone mRNA level, or serum corticosterone level. Consequently, we propose that CHC may induce a specific form of depressive-like behaviors via Treg reduction and microglial activation.
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spelling pubmed-56411502017-10-24 Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression Park, Hyun-Sun Han, Arum Yeo, Hye-Lim Park, Min-Jung You, Min-Jung Choi, Hyun Jin Hong, Chang-Won Lee, Sang-Hyuk Kim, Seung Hyun Kim, Borah Kwon, Min-Soo Oncotarget Research Paper Major depression has various types of symptoms and disease courses with inconsistent response to monoamine-related antidepressants. Thus, monoamine theory may not be the only pathophysiologic pathway relevant to depression. Recently, it has been suggested that regulatory T cell (Treg) is associated with depression. Based on our previous study that showed decreased regulatory T cell (Treg) population following chronic high-dose captopril (CHC, 40 mg/kg/day * 21 days) administration, we examined whether CHC alone can induce depressive-like behaviors in mice even without stressful stimuli. In this study, we found that CHC induced depressive-like behaviors in tail suspension test (TST) and forced swimming test (FST) without systemic illness, while it did not induce anhedonic behavior, anxiety-like behaviors, or sociality-related behavior. The depressive-like behaviors were rescued by either CHC washout or antidepressant. CHC caused reduction in foxp3 and gata3 mRNA expression in the lymph nodes with elevation in plasma IL-1β and IL-6. Interestingly, CHC increased serum angiotensin II level. In the hippocampus, CHC increased TNF-α and IL-6 mRNA expression with microglia activation while reduced glucocorticoid receptor expression. However, CHC did not affect to hippocampal kynurenine pathway, serotonin level, hypothalamic corticotropin-releasing hormone mRNA level, or serum corticosterone level. Consequently, we propose that CHC may induce a specific form of depressive-like behaviors via Treg reduction and microglial activation. Impact Journals LLC 2017-08-03 /pmc/articles/PMC5641150/ /pubmed/29069807 http://dx.doi.org/10.18632/oncotarget.19879 Text en Copyright: © 2017 Park et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Park, Hyun-Sun
Han, Arum
Yeo, Hye-Lim
Park, Min-Jung
You, Min-Jung
Choi, Hyun Jin
Hong, Chang-Won
Lee, Sang-Hyuk
Kim, Seung Hyun
Kim, Borah
Kwon, Min-Soo
Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression
title Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression
title_full Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression
title_fullStr Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression
title_full_unstemmed Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression
title_short Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression
title_sort chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory t cell in depression
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641150/
https://www.ncbi.nlm.nih.gov/pubmed/29069807
http://dx.doi.org/10.18632/oncotarget.19879
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