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Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression
Major depression has various types of symptoms and disease courses with inconsistent response to monoamine-related antidepressants. Thus, monoamine theory may not be the only pathophysiologic pathway relevant to depression. Recently, it has been suggested that regulatory T cell (Treg) is associated...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641150/ https://www.ncbi.nlm.nih.gov/pubmed/29069807 http://dx.doi.org/10.18632/oncotarget.19879 |
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author | Park, Hyun-Sun Han, Arum Yeo, Hye-Lim Park, Min-Jung You, Min-Jung Choi, Hyun Jin Hong, Chang-Won Lee, Sang-Hyuk Kim, Seung Hyun Kim, Borah Kwon, Min-Soo |
author_facet | Park, Hyun-Sun Han, Arum Yeo, Hye-Lim Park, Min-Jung You, Min-Jung Choi, Hyun Jin Hong, Chang-Won Lee, Sang-Hyuk Kim, Seung Hyun Kim, Borah Kwon, Min-Soo |
author_sort | Park, Hyun-Sun |
collection | PubMed |
description | Major depression has various types of symptoms and disease courses with inconsistent response to monoamine-related antidepressants. Thus, monoamine theory may not be the only pathophysiologic pathway relevant to depression. Recently, it has been suggested that regulatory T cell (Treg) is associated with depression. Based on our previous study that showed decreased regulatory T cell (Treg) population following chronic high-dose captopril (CHC, 40 mg/kg/day * 21 days) administration, we examined whether CHC alone can induce depressive-like behaviors in mice even without stressful stimuli. In this study, we found that CHC induced depressive-like behaviors in tail suspension test (TST) and forced swimming test (FST) without systemic illness, while it did not induce anhedonic behavior, anxiety-like behaviors, or sociality-related behavior. The depressive-like behaviors were rescued by either CHC washout or antidepressant. CHC caused reduction in foxp3 and gata3 mRNA expression in the lymph nodes with elevation in plasma IL-1β and IL-6. Interestingly, CHC increased serum angiotensin II level. In the hippocampus, CHC increased TNF-α and IL-6 mRNA expression with microglia activation while reduced glucocorticoid receptor expression. However, CHC did not affect to hippocampal kynurenine pathway, serotonin level, hypothalamic corticotropin-releasing hormone mRNA level, or serum corticosterone level. Consequently, we propose that CHC may induce a specific form of depressive-like behaviors via Treg reduction and microglial activation. |
format | Online Article Text |
id | pubmed-5641150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56411502017-10-24 Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression Park, Hyun-Sun Han, Arum Yeo, Hye-Lim Park, Min-Jung You, Min-Jung Choi, Hyun Jin Hong, Chang-Won Lee, Sang-Hyuk Kim, Seung Hyun Kim, Borah Kwon, Min-Soo Oncotarget Research Paper Major depression has various types of symptoms and disease courses with inconsistent response to monoamine-related antidepressants. Thus, monoamine theory may not be the only pathophysiologic pathway relevant to depression. Recently, it has been suggested that regulatory T cell (Treg) is associated with depression. Based on our previous study that showed decreased regulatory T cell (Treg) population following chronic high-dose captopril (CHC, 40 mg/kg/day * 21 days) administration, we examined whether CHC alone can induce depressive-like behaviors in mice even without stressful stimuli. In this study, we found that CHC induced depressive-like behaviors in tail suspension test (TST) and forced swimming test (FST) without systemic illness, while it did not induce anhedonic behavior, anxiety-like behaviors, or sociality-related behavior. The depressive-like behaviors were rescued by either CHC washout or antidepressant. CHC caused reduction in foxp3 and gata3 mRNA expression in the lymph nodes with elevation in plasma IL-1β and IL-6. Interestingly, CHC increased serum angiotensin II level. In the hippocampus, CHC increased TNF-α and IL-6 mRNA expression with microglia activation while reduced glucocorticoid receptor expression. However, CHC did not affect to hippocampal kynurenine pathway, serotonin level, hypothalamic corticotropin-releasing hormone mRNA level, or serum corticosterone level. Consequently, we propose that CHC may induce a specific form of depressive-like behaviors via Treg reduction and microglial activation. Impact Journals LLC 2017-08-03 /pmc/articles/PMC5641150/ /pubmed/29069807 http://dx.doi.org/10.18632/oncotarget.19879 Text en Copyright: © 2017 Park et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Park, Hyun-Sun Han, Arum Yeo, Hye-Lim Park, Min-Jung You, Min-Jung Choi, Hyun Jin Hong, Chang-Won Lee, Sang-Hyuk Kim, Seung Hyun Kim, Borah Kwon, Min-Soo Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression |
title | Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression |
title_full | Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression |
title_fullStr | Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression |
title_full_unstemmed | Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression |
title_short | Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression |
title_sort | chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory t cell in depression |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641150/ https://www.ncbi.nlm.nih.gov/pubmed/29069807 http://dx.doi.org/10.18632/oncotarget.19879 |
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