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Determinants of utilisation differences for cancer medicines in Belgium, Scotland and Sweden
BACKGROUND: Little comparative evidence is available on utilisation of cancer medicines in different countries and its determinants. The aim of this study was to develop a statistical model to test the correlation between utilisation and possible determinants in selected European countries. METHODS:...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641289/ https://www.ncbi.nlm.nih.gov/pubmed/27942986 http://dx.doi.org/10.1007/s10198-016-0855-5 |
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author | Ferrario, Alessandra |
author_facet | Ferrario, Alessandra |
author_sort | Ferrario, Alessandra |
collection | PubMed |
description | BACKGROUND: Little comparative evidence is available on utilisation of cancer medicines in different countries and its determinants. The aim of this study was to develop a statistical model to test the correlation between utilisation and possible determinants in selected European countries. METHODS: A sample of 31 medicines for cancer treatment that obtained EU-wide marketing authorisation between 2000 and 2012 was selected. Annual data on medicines’ utilisation covering the in- and out-patient public sectors were obtained from national authorities between 2008 and 2013. Possible determinants of utilisation were extracted from HTA reports and complemented by contacts with key informants. A longitudinal mixed effect model was fitted to test possible determinants of medicines utilisation in Belgium, Scotland and Sweden. RESULTS: In the all-country model, the number of indications reimbursed positively correlated with increased consumption of medicines [one indication 2.6, 95% CI (1.8–3.6); two indications 2.4, 95% CI (1.4–4.3); three indications 4.9, 95% CI (2.2–10.9); all P < 0.01], years since EU-wide marketing authorisation [1.2, 95% CI (1.02–1.4); p < 0.05], price per DDD [0.9, 95% CI (0.998–0.999), P < 0.01], and Prescrire rating [0.5, 95% CI (0.3–0.9), P < 0.05] after adjusting for time and other covariates. CONCLUSIONS: In this study, the most important correlates of increased utilisation in a sample of cancer medicines introduced in the past 15 years were: medicines coverage and time since marketing authorisation. Prices had a negative effect on consumption in Belgium and Sweden. The positive impact of financial MEAs in Scotland suggests that the latter may remove the regressive effect of list prices on consumption. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10198-016-0855-5) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5641289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-56412892017-10-26 Determinants of utilisation differences for cancer medicines in Belgium, Scotland and Sweden Ferrario, Alessandra Eur J Health Econ Original Paper BACKGROUND: Little comparative evidence is available on utilisation of cancer medicines in different countries and its determinants. The aim of this study was to develop a statistical model to test the correlation between utilisation and possible determinants in selected European countries. METHODS: A sample of 31 medicines for cancer treatment that obtained EU-wide marketing authorisation between 2000 and 2012 was selected. Annual data on medicines’ utilisation covering the in- and out-patient public sectors were obtained from national authorities between 2008 and 2013. Possible determinants of utilisation were extracted from HTA reports and complemented by contacts with key informants. A longitudinal mixed effect model was fitted to test possible determinants of medicines utilisation in Belgium, Scotland and Sweden. RESULTS: In the all-country model, the number of indications reimbursed positively correlated with increased consumption of medicines [one indication 2.6, 95% CI (1.8–3.6); two indications 2.4, 95% CI (1.4–4.3); three indications 4.9, 95% CI (2.2–10.9); all P < 0.01], years since EU-wide marketing authorisation [1.2, 95% CI (1.02–1.4); p < 0.05], price per DDD [0.9, 95% CI (0.998–0.999), P < 0.01], and Prescrire rating [0.5, 95% CI (0.3–0.9), P < 0.05] after adjusting for time and other covariates. CONCLUSIONS: In this study, the most important correlates of increased utilisation in a sample of cancer medicines introduced in the past 15 years were: medicines coverage and time since marketing authorisation. Prices had a negative effect on consumption in Belgium and Sweden. The positive impact of financial MEAs in Scotland suggests that the latter may remove the regressive effect of list prices on consumption. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10198-016-0855-5) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-12-09 2017 /pmc/articles/PMC5641289/ /pubmed/27942986 http://dx.doi.org/10.1007/s10198-016-0855-5 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Paper Ferrario, Alessandra Determinants of utilisation differences for cancer medicines in Belgium, Scotland and Sweden |
title | Determinants of utilisation differences for cancer medicines in Belgium, Scotland and Sweden |
title_full | Determinants of utilisation differences for cancer medicines in Belgium, Scotland and Sweden |
title_fullStr | Determinants of utilisation differences for cancer medicines in Belgium, Scotland and Sweden |
title_full_unstemmed | Determinants of utilisation differences for cancer medicines in Belgium, Scotland and Sweden |
title_short | Determinants of utilisation differences for cancer medicines in Belgium, Scotland and Sweden |
title_sort | determinants of utilisation differences for cancer medicines in belgium, scotland and sweden |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641289/ https://www.ncbi.nlm.nih.gov/pubmed/27942986 http://dx.doi.org/10.1007/s10198-016-0855-5 |
work_keys_str_mv | AT ferrarioalessandra determinantsofutilisationdifferencesforcancermedicinesinbelgiumscotlandandsweden |