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Aii810, a Novel Cold-Adapted N-Acylhomoserine Lactonase Discovered in a Metagenome, Can Strongly Attenuate Pseudomonas aeruginosa Virulence Factors and Biofilm Formation

The pathogen Pseudomonas aeruginosa uses quorum sensing (QS) to control virulence and biofilm formation. Enzymatic disruption of quorum sensing is a promising anti-infection therapeutic strategy that does not rely on antibiotics. Here, a novel gene (aii810) encoding an N-acylhomoserine lactonase was...

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Detalles Bibliográficos
Autores principales:	Fan, Xinjiong, Liang, Mingjun, Wang, Lei, Chen, Ruo, Li, He, Liu, Xiaolong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641347/ https://www.ncbi.nlm.nih.gov/pubmed/29067011 http://dx.doi.org/10.3389/fmicb.2017.01950

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