Sphingosine-1-Phosphate and the S1P(3) Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation

The bioactive lipid sphingosine-1-phosphate (S1P) is an important regulator in the nervous system. Here, we explored the role of S1P and its receptors in vitro and in preclinical models of peripheral nerve regeneration. Adult sensory neurons and motor neuron-like cells were exposed to S1P in an in v...

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Detalles Bibliográficos
Autores principales: Quarta, Serena, Camprubí-Robles, Maria, Schweigreiter, Rüdiger, Matusica, Dusan, Haberberger, Rainer V., Proia, Richard L., Bandtlow, Christine E., Ferrer-Montiel, Antonio, Kress, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641356/
https://www.ncbi.nlm.nih.gov/pubmed/29066950
http://dx.doi.org/10.3389/fnmol.2017.00317

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