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Could fertility-sparing surgery be considered for women with early stage ovarian clear cell carcinoma?
OBJECTIVE: The aim of the present retrospective population-based study was to investigate the oncologic impact of uterine and ovarian preservation (OP) in premenopausal women with stage IA or IC ovarian clear cell carcinoma (OCCC). METHODS: The National Cancer Institute's Surveillance, Epidemio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641522/ https://www.ncbi.nlm.nih.gov/pubmed/28758377 http://dx.doi.org/10.3802/jgo.2017.28.e71 |
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author | Nasioudis, Dimitrios Chapman-Davis, Eloise Frey, Melissa K. Witkin, Steven S. Holcomb, Kevin |
author_facet | Nasioudis, Dimitrios Chapman-Davis, Eloise Frey, Melissa K. Witkin, Steven S. Holcomb, Kevin |
author_sort | Nasioudis, Dimitrios |
collection | PubMed |
description | OBJECTIVE: The aim of the present retrospective population-based study was to investigate the oncologic impact of uterine and ovarian preservation (OP) in premenopausal women with stage IA or IC ovarian clear cell carcinoma (OCCC). METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was accessed and a cohort of surgically-staged premenopausal women (age <50 years) diagnosed with unilateral stage IA or IC OCCC was drawn. Based on site-specific surgery codes, women who did not undergo hysterectomy and/or bilateral salpingo-oophorectomy (BSO) were identified. Overall survival (OS) and cancer-specific survival (CSS) rates were calculated following generation of Kaplan-Meier curves; comparisons were made with the log-rank test. Multivariate Cox analysis was performed to control for possible confounders. RESULTS: A total of 741 premenopausal women who met the inclusion criteria were identified. Based on available information, rate of uterine preservation was 14.5% (96/663) while the rate of OP was 28.1% (71/253). Five-year CSS rates were 90.8% for women who did not undergo hysterectomy compared with 87.7% for those who did (p=0.290). Similarly, 5-year CSS rates in the OP and BSO groups were 92.6% and 85%, respectively (p=0.060). After controlling for disease sub-stage (IA vs. IC), uterine or OP was not associated with a worse overall or cancer-specific mortality. CONCLUSION: In the present cohort, uterine and OP did not have a negative impact on oncologic outcomes. Selection criteria for fertility-sparing surgery (FSS) could be expanded to include women with stage IA OCCC. |
format | Online Article Text |
id | pubmed-5641522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-56415222017-11-01 Could fertility-sparing surgery be considered for women with early stage ovarian clear cell carcinoma? Nasioudis, Dimitrios Chapman-Davis, Eloise Frey, Melissa K. Witkin, Steven S. Holcomb, Kevin J Gynecol Oncol Original Article OBJECTIVE: The aim of the present retrospective population-based study was to investigate the oncologic impact of uterine and ovarian preservation (OP) in premenopausal women with stage IA or IC ovarian clear cell carcinoma (OCCC). METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was accessed and a cohort of surgically-staged premenopausal women (age <50 years) diagnosed with unilateral stage IA or IC OCCC was drawn. Based on site-specific surgery codes, women who did not undergo hysterectomy and/or bilateral salpingo-oophorectomy (BSO) were identified. Overall survival (OS) and cancer-specific survival (CSS) rates were calculated following generation of Kaplan-Meier curves; comparisons were made with the log-rank test. Multivariate Cox analysis was performed to control for possible confounders. RESULTS: A total of 741 premenopausal women who met the inclusion criteria were identified. Based on available information, rate of uterine preservation was 14.5% (96/663) while the rate of OP was 28.1% (71/253). Five-year CSS rates were 90.8% for women who did not undergo hysterectomy compared with 87.7% for those who did (p=0.290). Similarly, 5-year CSS rates in the OP and BSO groups were 92.6% and 85%, respectively (p=0.060). After controlling for disease sub-stage (IA vs. IC), uterine or OP was not associated with a worse overall or cancer-specific mortality. CONCLUSION: In the present cohort, uterine and OP did not have a negative impact on oncologic outcomes. Selection criteria for fertility-sparing surgery (FSS) could be expanded to include women with stage IA OCCC. Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology 2017-11 2017-07-03 /pmc/articles/PMC5641522/ /pubmed/28758377 http://dx.doi.org/10.3802/jgo.2017.28.e71 Text en Copyright © 2017. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Nasioudis, Dimitrios Chapman-Davis, Eloise Frey, Melissa K. Witkin, Steven S. Holcomb, Kevin Could fertility-sparing surgery be considered for women with early stage ovarian clear cell carcinoma? |
title | Could fertility-sparing surgery be considered for women with early stage ovarian clear cell carcinoma? |
title_full | Could fertility-sparing surgery be considered for women with early stage ovarian clear cell carcinoma? |
title_fullStr | Could fertility-sparing surgery be considered for women with early stage ovarian clear cell carcinoma? |
title_full_unstemmed | Could fertility-sparing surgery be considered for women with early stage ovarian clear cell carcinoma? |
title_short | Could fertility-sparing surgery be considered for women with early stage ovarian clear cell carcinoma? |
title_sort | could fertility-sparing surgery be considered for women with early stage ovarian clear cell carcinoma? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641522/ https://www.ncbi.nlm.nih.gov/pubmed/28758377 http://dx.doi.org/10.3802/jgo.2017.28.e71 |
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