Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes

OBJECTIVE: Hyperglucagonemia is present in many forms of diabetes and contributes to hyperglycemia, and glucagon suppression can ameliorate diabetes in mice. Leptin, a glucagon suppressor, can also reverse diabetes in rodents. Lipid nanoparticle (LNP) delivery of small interfering RNA (siRNA) effect...

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Detalles Bibliográficos
Autores principales: Neumann, Ursula H., Ho, Jessica S.S., Chen, Sam, Tam, Yuen Yi C., Cullis, Pieter R., Kieffer, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641600/
https://www.ncbi.nlm.nih.gov/pubmed/29031717
http://dx.doi.org/10.1016/j.molmet.2017.06.012

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