Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss

OBJECTIVE: The mitochondrial uncoupling agent 2,4-dinitrophenol (DNP), historically used as a treatment for obesity, is known to cross the blood-brain-barrier, but its effects on central neural circuits controlling body weight are largely unknown. As hypothalamic melanocortin neuropeptide Y/agouti-r...

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Detalles Bibliográficos
Autores principales: Michael, Natalie Jane, Simonds, Stephanie Elise, van den Top, Marco, Cowley, Michael Alexander, Spanswick, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641603/
https://www.ncbi.nlm.nih.gov/pubmed/29031712
http://dx.doi.org/10.1016/j.molmet.2017.07.002

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