Cargando…

Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling

OBJECTIVE: In visceral obesity, an overactive endocannabinoid/CB(1) receptor (CB(1)R) system promotes increased caloric intake and decreases energy expenditure, which are mitigated by global or peripheral CB(1)R blockade. In mice with diet-induced obesity (DIO), inhibition of food intake by the peri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tam, Joseph, Szanda, Gergő, Drori, Adi, Liu, Ziyi, Cinar, Resat, Kashiwaya, Yoshihiro, Reitman, Marc L., Kunos, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641628/ https://www.ncbi.nlm.nih.gov/pubmed/29031713 http://dx.doi.org/10.1016/j.molmet.2017.06.010

Ejemplares similares

Cannabinoid receptor type 1 (CB(1)R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3
por: Szanda, Gergő, et al.
Publicado: (2023)

CB(1)R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance
por: Drori, Adi, et al.
Publicado: (2020)

Dual inhibition of cannabinoid CB(1) receptor and inducible NOS attenuates obesity‐induced chronic kidney disease
por: Udi, Shiran, et al.
Publicado: (2019)

SUN-665 Peripheral CB(1)R Blocker Improves Metabolism in Diet Induced Obese Mice Independent of Hepatic FGF21
por: Liu, Jie, et al.
Publicado: (2020)

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue
por: Godlewski, Grzegorz, et al.
Publicado: (2015)

Editorial: Multifaceted Cannabinoids: Regulators of Normal and Pathological Function in Metabolic and Endocrine Organs
por: Szanda, Gergő, et al.
Publicado: (2022)

Cholesterol as a modulator of cannabinoid receptor CB(2) signaling
por: Yeliseev, Alexei, et al.
Publicado: (2021)

Synthetic cannabinoids induce acute lung inflammation via cannabinoid receptor 1 activation
por: Zawatsky, Charles N., et al.
Publicado: (2020)

Peripheral Cannabinoid-1 Receptor Blockade Ameliorates Cystitis Severity
por: Hinden, Liad, et al.
Publicado: (2023)

Cannabinoid‐1 receptor regulates mitochondrial dynamics and function in renal proximal tubular cells
por: Drori, Adi, et al.
Publicado: (2018)

SUN-LB081 LXR Agonist 25-Hydroxycholesterol Modulates Plasma, Adrenal, and Hypothalamic Phosphoethanolamine Levels: Neuroendocrine Implications for HPA-Axis in Major Depressive Disorder
por: Osei-Hyiaman, Douglas, et al.
Publicado: (2019)

Functional Selectivity of a Biased Cannabinoid-1 Receptor (CB(1)R) Antagonist
por: Liu, Ziyi, et al.
Publicado: (2021)

Peripheral Hybrid CB(1)R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis
por: Zawatsky, Charles N., et al.
Publicado: (2021)

Optimization of the Heterologous Expression of the Cannabinoid Type-1 (CB(1)) Receptor
por: Horváth, Viktória B., et al.
Publicado: (2021)

Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions
por: Iio, Wataru, et al.
Publicado: (2014)

Environment, Leptin Sensitivity, and Hypothalamic Plasticity
por: Mainardi, Marco, et al.
Publicado: (2013)

Renal Proximal Tubule Cell Cannabinoid-1 Receptor Regulates Bone Remodeling and Mass via a Kidney-to-Bone Axis
por: Baraghithy, Saja, et al.
Publicado: (2021)

Hypothalamic Leptin Resistance: From BBB to BBSome
por: López, Miguel
Publicado: (2016)

Hypothalamic PKA regulates leptin sensitivity and adiposity
por: Yang, Linghai, et al.
Publicado: (2015)

Tanycyte-Independent Control of Hypothalamic Leptin Signaling
por: Yoo, Sooyeon, et al.
Publicado: (2019)

Hypothalamic TTF-1 orchestrates the sensitivity of leptin
por: Park, Byong Seo, et al.
Publicado: (2022)

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia
por: Santos-Molina, Luis, et al.
Publicado: (2021)

Circadian rhythm in hypothalamic leptin receptor (Ob-Rb) mRNA expressions and cerebrospinal fluid and circulating glucose and leptin levels in lactating rats
por: Suzuki, Yoshihiro, et al.
Publicado: (2021)

Hypothalamic leptin action is mediated by histone deacetylase 5
por: Kabra, Dhiraj G., et al.
Publicado: (2016)

Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior
por: Jeong, Bora, et al.
Publicado: (2022)

Signaling Interactions in the Adrenal Cortex
por: Spät, András, et al.
Publicado: (2016)

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin
por: Rahmouni, Kamal, et al.
Publicado: (2009)

Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin
por: Fruhwürth, Stefanie, et al.
Publicado: (2018)

Distinct Effects of Leptin and a Melanocortin Receptor Agonist Injected Into Medial Hypothalamic Nuclei on Glucose Uptake in Peripheral Tissues
por: Toda, Chitoku, et al.
Publicado: (2009)

Specific Features of the Hypothalamic Leptin Signaling Response to Cold Exposure Are Reflected in Peripheral Blood Mononuclear Cells in Rats and Ferrets
por: Reynés, Bàrbara, et al.
Publicado: (2017)

Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids
por: Gunduz-Cinar, Ozge, et al.
Publicado: (2016)

Distinct Subsets of Lateral Hypothalamic Neurotensin Neurons are Activated by Leptin or Dehydration
por: Brown, Juliette A., et al.
Publicado: (2019)

A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity
por: Zheng, Hong, et al.
Publicado: (2017)

A leptin-responsive hypothalamic circuit inputs to the circadian feeding network
por: Tang, Qijun, et al.
Publicado: (2023)

Endocannabinoid System and Cannabinoid 1 Receptors in Patients With Pharmacoresistant Temporal Lobe Epilepsy and Comorbid Mood Disorders
por: Rocha, Luisa, et al.
Publicado: (2020)

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy
por: Rajesh, Mohanraj, et al.
Publicado: (2012)

Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–CB1-R Signaling
por: Paloczi, Janos, et al.
Publicado: (2019)

The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics
por: Mukhopadhyay, Bani, et al.
Publicado: (2023)

Synergistic cytotoxic activity of cannabinoids from cannabis sativa against cutaneous T-cell lymphoma (CTCL) in-vitro and ex-vivo
por: Mazuz, Moran, et al.
Publicado: (2020)

Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent
por: Azar, Shahar, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r3o447q5l6fu03bu9ecciatd4d