Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice

OBJECTIVE: Hypothalamic arcuate nucleus-specific pro-opiomelanocortin deficient (ArcPomc(−/−)) mice exhibit improved glucose tolerance despite massive obesity and insulin resistance. We demonstrated previously that their improved glucose tolerance is due to elevated glycosuria. However, the underlyi...

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Detalles Bibliográficos
Autores principales: Chhabra, Kavaljit H., Morgan, Donald A., Tooke, Benjamin P., Adams, Jessica M., Rahmouni, Kamal, Low, Malcolm J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641634/
https://www.ncbi.nlm.nih.gov/pubmed/29031726
http://dx.doi.org/10.1016/j.molmet.2017.07.005

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