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Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry

Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron‐demand Diels–Alder reaction. Inspired by recent accomplishments in pre‐targeted imaging using tetrazine‐trans‐cyclooctene click c...

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Autores principales: Brand, Christian, Iacono, Pasquale, Pérez‐Medina, Carlos, Mulder, Willem J. M., Kircher, Moritz F., Reiner, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641912/
https://www.ncbi.nlm.nih.gov/pubmed/29046855
http://dx.doi.org/10.1002/open.201700105
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author Brand, Christian
Iacono, Pasquale
Pérez‐Medina, Carlos
Mulder, Willem J. M.
Kircher, Moritz F.
Reiner, Thomas
author_facet Brand, Christian
Iacono, Pasquale
Pérez‐Medina, Carlos
Mulder, Willem J. M.
Kircher, Moritz F.
Reiner, Thomas
author_sort Brand, Christian
collection PubMed
description Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron‐demand Diels–Alder reaction. Inspired by recent accomplishments in pre‐targeted imaging using tetrazine‐trans‐cyclooctene click chemistry, we synthesized (89)Zr‐labeled trans‐cyclooctene‐functionalized liposomal nanoparticles, which were validated on a tetrazine‐appended polydopamine‐coated CoCrMo surface. In efforts to ultimately translate this new material to biomedical applications, we compared the ability of (89)Zr‐TCO–liposomal nanoparticles ((89)Zr‐TCO‐LNP) to be immobilized on the tetrazine surface to the control suspensions of non‐TCO functionalized (89)Zr‐liposomal nanoparticles. Ultimately, this platform technology could result in a systemic decrease of the radiotherapeutic dose deposited in non‐targeted tissues by specific removal of long‐circulating liposomal radiopharmaceuticals from the blood pool.
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spelling pubmed-56419122017-10-18 Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry Brand, Christian Iacono, Pasquale Pérez‐Medina, Carlos Mulder, Willem J. M. Kircher, Moritz F. Reiner, Thomas ChemistryOpen Communications Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron‐demand Diels–Alder reaction. Inspired by recent accomplishments in pre‐targeted imaging using tetrazine‐trans‐cyclooctene click chemistry, we synthesized (89)Zr‐labeled trans‐cyclooctene‐functionalized liposomal nanoparticles, which were validated on a tetrazine‐appended polydopamine‐coated CoCrMo surface. In efforts to ultimately translate this new material to biomedical applications, we compared the ability of (89)Zr‐TCO–liposomal nanoparticles ((89)Zr‐TCO‐LNP) to be immobilized on the tetrazine surface to the control suspensions of non‐TCO functionalized (89)Zr‐liposomal nanoparticles. Ultimately, this platform technology could result in a systemic decrease of the radiotherapeutic dose deposited in non‐targeted tissues by specific removal of long‐circulating liposomal radiopharmaceuticals from the blood pool. John Wiley and Sons Inc. 2017-08-07 /pmc/articles/PMC5641912/ /pubmed/29046855 http://dx.doi.org/10.1002/open.201700105 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Brand, Christian
Iacono, Pasquale
Pérez‐Medina, Carlos
Mulder, Willem J. M.
Kircher, Moritz F.
Reiner, Thomas
Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry
title Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry
title_full Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry
title_fullStr Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry
title_full_unstemmed Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry
title_short Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry
title_sort specific binding of liposomal nanoparticles through inverse electron‐demand diels–alder click chemistry
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641912/
https://www.ncbi.nlm.nih.gov/pubmed/29046855
http://dx.doi.org/10.1002/open.201700105
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