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Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry
Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron‐demand Diels–Alder reaction. Inspired by recent accomplishments in pre‐targeted imaging using tetrazine‐trans‐cyclooctene click c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641912/ https://www.ncbi.nlm.nih.gov/pubmed/29046855 http://dx.doi.org/10.1002/open.201700105 |
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author | Brand, Christian Iacono, Pasquale Pérez‐Medina, Carlos Mulder, Willem J. M. Kircher, Moritz F. Reiner, Thomas |
author_facet | Brand, Christian Iacono, Pasquale Pérez‐Medina, Carlos Mulder, Willem J. M. Kircher, Moritz F. Reiner, Thomas |
author_sort | Brand, Christian |
collection | PubMed |
description | Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron‐demand Diels–Alder reaction. Inspired by recent accomplishments in pre‐targeted imaging using tetrazine‐trans‐cyclooctene click chemistry, we synthesized (89)Zr‐labeled trans‐cyclooctene‐functionalized liposomal nanoparticles, which were validated on a tetrazine‐appended polydopamine‐coated CoCrMo surface. In efforts to ultimately translate this new material to biomedical applications, we compared the ability of (89)Zr‐TCO–liposomal nanoparticles ((89)Zr‐TCO‐LNP) to be immobilized on the tetrazine surface to the control suspensions of non‐TCO functionalized (89)Zr‐liposomal nanoparticles. Ultimately, this platform technology could result in a systemic decrease of the radiotherapeutic dose deposited in non‐targeted tissues by specific removal of long‐circulating liposomal radiopharmaceuticals from the blood pool. |
format | Online Article Text |
id | pubmed-5641912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56419122017-10-18 Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry Brand, Christian Iacono, Pasquale Pérez‐Medina, Carlos Mulder, Willem J. M. Kircher, Moritz F. Reiner, Thomas ChemistryOpen Communications Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron‐demand Diels–Alder reaction. Inspired by recent accomplishments in pre‐targeted imaging using tetrazine‐trans‐cyclooctene click chemistry, we synthesized (89)Zr‐labeled trans‐cyclooctene‐functionalized liposomal nanoparticles, which were validated on a tetrazine‐appended polydopamine‐coated CoCrMo surface. In efforts to ultimately translate this new material to biomedical applications, we compared the ability of (89)Zr‐TCO–liposomal nanoparticles ((89)Zr‐TCO‐LNP) to be immobilized on the tetrazine surface to the control suspensions of non‐TCO functionalized (89)Zr‐liposomal nanoparticles. Ultimately, this platform technology could result in a systemic decrease of the radiotherapeutic dose deposited in non‐targeted tissues by specific removal of long‐circulating liposomal radiopharmaceuticals from the blood pool. John Wiley and Sons Inc. 2017-08-07 /pmc/articles/PMC5641912/ /pubmed/29046855 http://dx.doi.org/10.1002/open.201700105 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Communications Brand, Christian Iacono, Pasquale Pérez‐Medina, Carlos Mulder, Willem J. M. Kircher, Moritz F. Reiner, Thomas Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry |
title | Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry |
title_full | Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry |
title_fullStr | Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry |
title_full_unstemmed | Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry |
title_short | Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry |
title_sort | specific binding of liposomal nanoparticles through inverse electron‐demand diels–alder click chemistry |
topic | Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641912/ https://www.ncbi.nlm.nih.gov/pubmed/29046855 http://dx.doi.org/10.1002/open.201700105 |
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