Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril

The chemoenzymatic flow synthesis of enantiomerically pure captopril, a widely used antihypertensive drug, is accomplished starting from simple, inexpensive, and readily available reagents. The first step is a heterogeneous biocatalyzed regio‐ and stereoselective oxidation of cheap prochiral 2‐methy...

Descripción completa

Detalles Bibliográficos
Autores principales: De Vitis, Valerio, Dall'Oglio, Federica, Pinto, Andrea, De Micheli, Carlo, Molinari, Francesco, Conti, Paola, Romano, Diego, Tamborini, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641918/
https://www.ncbi.nlm.nih.gov/pubmed/29046862
http://dx.doi.org/10.1002/open.201700082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641918/
https://www.ncbi.nlm.nih.gov/pubmed/29046862
http://dx.doi.org/10.1002/open.201700082

Ejemplares similares