The dual role of poly(ADP-ribose) polymerase-1 in modulating parthanatos and autophagy under oxidative stress in rat cochlear marginal cells of the stria vascularis

Oxidative stress is reported to regulate several apoptotic and necrotic cell death pathways in auditory tissues. Poly(ADP-ribose) polymerase-1 (PARP-1) can be activated under oxidative stress, which is the hallmark of parthanatos. Autophagy, which serves either a pro-survival or pro-death function,...

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Detalles Bibliográficos
Autores principales: Jiang, Hong-Yan, Yang, Yang, Zhang, Yuan-Yuan, Xie, Zhen, Zhao, Xue-Yan, Sun, Yu, Kong, Wei-Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641921/
https://www.ncbi.nlm.nih.gov/pubmed/29049980
http://dx.doi.org/10.1016/j.redox.2017.10.002

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