Cargando…

Metabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

BACKGROUND: One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification of potential treatment response biomarkers are of great clinical significance....

Descripción completa

Detalles Bibliográficos
Autores principales:	Bjerrum, Jacob Tveiten, Steenholdt, Casper, Ainsworth, Mark, Nielsen, Ole Haagen, Reed, Michelle AC, Atkins, Karen, Günther, Ulrich Leonhard, Hao, Fuhua, Wang, Yulan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641999/ https://www.ncbi.nlm.nih.gov/pubmed/29032767 http://dx.doi.org/10.1186/s12916-017-0949-7

Ejemplares similares

Metabonomics in Gastroenterology and Hepatology
por: Bjerrum, Jacob Tveiten, et al.
Publicado: (2019)

Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn’s disease and healthy individuals
por: Bjerrum, Jacob Tveiten, et al.
Publicado: (2014)

Integration of transcriptomics and metabonomics: improving diagnostics, biomarker identification and phenotyping in ulcerative colitis
por: Bjerrum, Jacob Tveiten, et al.
Publicado: (2013)

Efficacy and safety of methotrexate in the management of inflammatory bowel disease: A systematic review and meta-analysis of randomized, controlled trials
por: Nielsen, Ole Haagen, et al.
Publicado: (2020)

Circulating Cytokines and Cytokine Receptors in Infliximab Treatment Failure Due to TNF-α Independent Crohn Disease
por: Steenholdt, Casper, et al.
Publicado: (2016)

IBD metabonomics predicts phenotype, disease course, and treatment response
por: Bjerrum, Jacob T., et al.
Publicado: (2021)

Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets
por: Bjerrum, Jacob Tveiten, et al.
Publicado: (2022)

Putative biomarkers of vedolizumab resistance and underlying inflammatory pathways involved in IBD
por: Soendergaard, Christoffer, et al.
Publicado: (2018)

Influence of Smoking on Colonic Gene Expression Profile in Crohn's Disease
por: Nielsen, Ole Haagen, et al.
Publicado: (2009)

Discontinuation of infliximab therapy in patients with Crohn's disease in sustained complete remission (the STOP IT study): protocol for a double-blind, randomised, placebo-controlled, multicentre trial
por: Buhl, Sine Schnoor, et al.
Publicado: (2014)

Infliximab clearance decreases in the second and third trimesters of pregnancy in inflammatory bowel disease
por: Grišić, Ana‐Marija, et al.
Publicado: (2021)

Management of Iron-Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review
por: Nielsen, Ole Haagen, et al.
Publicado: (2015)

New Strategies for Treatment of Inflammatory Bowel Disease
por: Nielsen, Ole Haagen
Publicado: (2014)

Sex Differences in Proatherogenic Cytokine Levels
por: Bernardi, Stella, et al.
Publicado: (2020)

Correlations of Fecal Metabonomic and Microbiomic Changes Induced by High-fat Diet in the Pre-Obesity State
por: Lin, Hong, et al.
Publicado: (2016)

Oxidized Phospholipids are Proinflammatory and Proatherogenic in Hypercholesterolemic Mice
por: Que, Xuchu, et al.
Publicado: (2018)

Identifying and understanding disease burden in patients with inflammatory bowel disease
por: Christensen, Katrine Risager, et al.
Publicado: (2022)

Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis
por: Potor, László, et al.
Publicado: (2021)

miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages
por: Nguyen, My-Anh, et al.
Publicado: (2022)

Infliximab in inflammatory bowel disease
por: Papamichael, Konstantinos, et al.
Publicado: (2019)

Rational Management of Iron-Deficiency Anaemia in Inflammatory Bowel Disease
por: Nielsen, Ole Haagen, et al.
Publicado: (2018)

Brief Report: Proatherogenic Cytokine Microenvironment in the Aortic Adventitia of Patients With Rheumatoid Arthritis
por: Ahmed, Ammad, et al.
Publicado: (2016)

The impact of dapagliflozin on glucose excursions related to early proatherogenic derangement in the aortic wall()
por: Stelmaszyk, Agnieszka, et al.
Publicado: (2018)

Integrative metabonomics as potential method for diagnosis of thyroid malignancy
por: Tian, Yuan, et al.
Publicado: (2015)

Managing vitamin D deficiency in inflammatory bowel disease
por: Nielsen, Ole Haagen, et al.
Publicado: (2019)

Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review
por: Démaris, Alix, et al.
Publicado: (2022)

Identification of TNF-α-Responsive Promoters and Enhancers in the Intestinal Epithelial Cell Model Caco-2
por: Boyd, Mette, et al.
Publicado: (2014)

Lipoprotein Subfraction Cholesterol Distribution Is Proatherogenic in Women With Type 1 Diabetes and Insulin Resistance
por: Maahs, David M., et al.
Publicado: (2010)

Hyperglycemia-Induced Metabolic Reprogramming Mediates a Proatherogenic Phenotype in Healthy Human Monocytes
por: Castro-Grattoni, Anabel Lourdes, et al.
Publicado: (2021)

Tissue Metabonomic Phenotyping for Diagnosis and Prognosis of Human Colorectal Cancer
por: Tian, Yuan, et al.
Publicado: (2016)

Inflammatory bowel disease of the lung: The role of infliximab?()
por: Hayek, Adam J., et al.
Publicado: (2015)

Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections
por: Li, Jia V., et al.
Publicado: (2011)

COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis
por: Holmstroem, Rikke Boedker, et al.
Publicado: (2022)

Efficacy of Infliximab Biosimilar for Maintenance Therapy in Pediatric Inflammatory Bowel Disease Following Infliximab Originator
por: Hinshaw, Amie, et al.
Publicado: (2022)

Genetic Disruption of Myostatin Reduces the Development of Proatherogenic Dyslipidemia and Atherogenic Lesions In Ldlr Null Mice
por: Tu, Powen, et al.
Publicado: (2009)

Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery
por: Trøseid, Marius, et al.
Publicado: (2016)

Adipose‐Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization
por: Xie, Zulong, et al.
Publicado: (2018)

Genetic Attenuation of Paraoxonase 1 Activity Induces Proatherogenic Changes in Plasma Proteomes of Mice and Humans
por: Sikora, Marta, et al.
Publicado: (2020)

NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli
por: Linna-Kuosmanen, Suvi, et al.
Publicado: (2020)

Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside
por: Mezentsev, Alexandre, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_piocr8542kucgbfbopvjs8se33