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Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson's Disease

Soluble guanylate cyclase (sGC) is an important transducing enzyme of cyclic guanosine monophosphate (cGMP) signaling pathway in striatum which has been considered as a potential target for the treatment of Parkinson's disease. Etiology of Parkinson's disease is multifactorial, finally res...

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Autores principales: Ghanta, Mohankrishna, Panchanathan, Elango, Lakkakula, Bhaskar V. K. S., Narayanaswamy, Anbumani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642137/
https://www.ncbi.nlm.nih.gov/pubmed/29081615
http://dx.doi.org/10.4103/jpp.JPP_45_17
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author Ghanta, Mohankrishna
Panchanathan, Elango
Lakkakula, Bhaskar V. K. S.
Narayanaswamy, Anbumani
author_facet Ghanta, Mohankrishna
Panchanathan, Elango
Lakkakula, Bhaskar V. K. S.
Narayanaswamy, Anbumani
author_sort Ghanta, Mohankrishna
collection PubMed
description Soluble guanylate cyclase (sGC) is an important transducing enzyme of cyclic guanosine monophosphate (cGMP) signaling pathway in striatum which has been considered as a potential target for the treatment of Parkinson's disease. Etiology of Parkinson's disease is multifactorial, finally resulting in abnormal proteinopathies causing degeneration of nigrostriatal pathways. Understanding the pathological basis of Parkinson's disease at molecular level is still an achievable target for the researchers and clinical practitioners. sGCs may be one of the causative factors resulting in Parkinson's disease due to glutamate toxicity or other event. This review presents the literature from articles of past five decades nearly as still this enzyme protein and its role in Parkinson's disease is not that clearly understood or presented till date. Recent interventions of this protein inhibition in the treatment of Parkinson's disease preclinically gave a chance to review the literature about this enzyme and its correlation with factors causing Parkinson's disease. We explored literature using PubMed and EMBASE for the role of sGC in Parkinson's disease. Databases were searched using the following terms: Parkinson's disease, neurotoxins, guanylate cyclase, sGC-cGMP pathway, and neurodegeneration. This review listed out the factors that have probability for stimulating sGC which already have been listed as a neurotoxins causing Parkinson's disease.
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spelling pubmed-56421372017-10-27 Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson's Disease Ghanta, Mohankrishna Panchanathan, Elango Lakkakula, Bhaskar V. K. S. Narayanaswamy, Anbumani J Pharmacol Pharmacother Review Article Soluble guanylate cyclase (sGC) is an important transducing enzyme of cyclic guanosine monophosphate (cGMP) signaling pathway in striatum which has been considered as a potential target for the treatment of Parkinson's disease. Etiology of Parkinson's disease is multifactorial, finally resulting in abnormal proteinopathies causing degeneration of nigrostriatal pathways. Understanding the pathological basis of Parkinson's disease at molecular level is still an achievable target for the researchers and clinical practitioners. sGCs may be one of the causative factors resulting in Parkinson's disease due to glutamate toxicity or other event. This review presents the literature from articles of past five decades nearly as still this enzyme protein and its role in Parkinson's disease is not that clearly understood or presented till date. Recent interventions of this protein inhibition in the treatment of Parkinson's disease preclinically gave a chance to review the literature about this enzyme and its correlation with factors causing Parkinson's disease. We explored literature using PubMed and EMBASE for the role of sGC in Parkinson's disease. Databases were searched using the following terms: Parkinson's disease, neurotoxins, guanylate cyclase, sGC-cGMP pathway, and neurodegeneration. This review listed out the factors that have probability for stimulating sGC which already have been listed as a neurotoxins causing Parkinson's disease. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5642137/ /pubmed/29081615 http://dx.doi.org/10.4103/jpp.JPP_45_17 Text en Copyright: © 2017 Journal of Pharmacology and Pharmacotherapeutics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Ghanta, Mohankrishna
Panchanathan, Elango
Lakkakula, Bhaskar V. K. S.
Narayanaswamy, Anbumani
Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson's Disease
title Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson's Disease
title_full Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson's Disease
title_fullStr Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson's Disease
title_full_unstemmed Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson's Disease
title_short Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson's Disease
title_sort retrospection on the role of soluble guanylate cyclase in parkinson's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642137/
https://www.ncbi.nlm.nih.gov/pubmed/29081615
http://dx.doi.org/10.4103/jpp.JPP_45_17
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