Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines

We herein describe a palladium-catalyzed formal aromaticity transfer coupling reaction between phenols and pyrrolidines or indolines to generate the corresponding N-cyclohexyl pyrroles or indoles. In this transformation, the aromaticity of phenols is formally passed on to the pyrrolidine or indoline...

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Detalles Bibliográficos
Autores principales: Qiu, Zihang, Li, Jiang-Sheng, Li, Chao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642148/
https://www.ncbi.nlm.nih.gov/pubmed/29147521
http://dx.doi.org/10.1039/c7sc02578e
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author Qiu, Zihang
Li, Jiang-Sheng
Li, Chao-Jun
author_facet Qiu, Zihang
Li, Jiang-Sheng
Li, Chao-Jun
author_sort Qiu, Zihang
collection PubMed
description We herein describe a palladium-catalyzed formal aromaticity transfer coupling reaction between phenols and pyrrolidines or indolines to generate the corresponding N-cyclohexyl pyrroles or indoles. In this transformation, the aromaticity of phenols is formally passed on to the pyrrolidine or indoline units. Substituted phenols thus can serve as latent cyclohexyl equivalents for the fast construction of various N-cyclohexyl pyrroles and indoles.
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spelling pubmed-56421482017-11-16 Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines Qiu, Zihang Li, Jiang-Sheng Li, Chao-Jun Chem Sci Chemistry We herein describe a palladium-catalyzed formal aromaticity transfer coupling reaction between phenols and pyrrolidines or indolines to generate the corresponding N-cyclohexyl pyrroles or indoles. In this transformation, the aromaticity of phenols is formally passed on to the pyrrolidine or indoline units. Substituted phenols thus can serve as latent cyclohexyl equivalents for the fast construction of various N-cyclohexyl pyrroles and indoles. Royal Society of Chemistry 2017-10-01 2017-08-10 /pmc/articles/PMC5642148/ /pubmed/29147521 http://dx.doi.org/10.1039/c7sc02578e Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Qiu, Zihang
Li, Jiang-Sheng
Li, Chao-Jun
Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines
title Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines
title_full Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines
title_fullStr Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines
title_full_unstemmed Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines
title_short Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines
title_sort formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642148/
https://www.ncbi.nlm.nih.gov/pubmed/29147521
http://dx.doi.org/10.1039/c7sc02578e
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AT lijiangsheng formalaromaticitytransferforpalladiumcatalyzedcouplingbetweenphenolsandpyrrolidinesindolines
AT lichaojun formalaromaticitytransferforpalladiumcatalyzedcouplingbetweenphenolsandpyrrolidinesindolines

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