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Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate

Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between...

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Detalles Bibliográficos
Autores principales: Schöchl, Herbert, Grottke, Oliver, Sutor, Ken, Dony, Kieron, Schreiber, Martin, Ranucci, Marco, Collins, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642320/
https://www.ncbi.nlm.nih.gov/pubmed/28857856
http://dx.doi.org/10.1213/ANE.0000000000002410
Descripción
Sumario:Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used.