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Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate

Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between...

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Autores principales: Schöchl, Herbert, Grottke, Oliver, Sutor, Ken, Dony, Kieron, Schreiber, Martin, Ranucci, Marco, Collins, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642320/
https://www.ncbi.nlm.nih.gov/pubmed/28857856
http://dx.doi.org/10.1213/ANE.0000000000002410
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author Schöchl, Herbert
Grottke, Oliver
Sutor, Ken
Dony, Kieron
Schreiber, Martin
Ranucci, Marco
Collins, Peter W.
author_facet Schöchl, Herbert
Grottke, Oliver
Sutor, Ken
Dony, Kieron
Schreiber, Martin
Ranucci, Marco
Collins, Peter W.
author_sort Schöchl, Herbert
collection PubMed
description Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used.
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spelling pubmed-56423202017-10-24 Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate Schöchl, Herbert Grottke, Oliver Sutor, Ken Dony, Kieron Schreiber, Martin Ranucci, Marco Collins, Peter W. Anesth Analg Hemostasis Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used. Lippincott Williams & Wilkins 2017-11 2017-08-24 /pmc/articles/PMC5642320/ /pubmed/28857856 http://dx.doi.org/10.1213/ANE.0000000000002410 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Anesthesia Research Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Hemostasis
Schöchl, Herbert
Grottke, Oliver
Sutor, Ken
Dony, Kieron
Schreiber, Martin
Ranucci, Marco
Collins, Peter W.
Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate
title Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate
title_full Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate
title_fullStr Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate
title_full_unstemmed Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate
title_short Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate
title_sort theoretical modeling of coagulation management with therapeutic plasma or prothrombin complex concentrate
topic Hemostasis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642320/
https://www.ncbi.nlm.nih.gov/pubmed/28857856
http://dx.doi.org/10.1213/ANE.0000000000002410
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