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Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate
Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642320/ https://www.ncbi.nlm.nih.gov/pubmed/28857856 http://dx.doi.org/10.1213/ANE.0000000000002410 |
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author | Schöchl, Herbert Grottke, Oliver Sutor, Ken Dony, Kieron Schreiber, Martin Ranucci, Marco Collins, Peter W. |
author_facet | Schöchl, Herbert Grottke, Oliver Sutor, Ken Dony, Kieron Schreiber, Martin Ranucci, Marco Collins, Peter W. |
author_sort | Schöchl, Herbert |
collection | PubMed |
description | Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used. |
format | Online Article Text |
id | pubmed-5642320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-56423202017-10-24 Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate Schöchl, Herbert Grottke, Oliver Sutor, Ken Dony, Kieron Schreiber, Martin Ranucci, Marco Collins, Peter W. Anesth Analg Hemostasis Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used. Lippincott Williams & Wilkins 2017-11 2017-08-24 /pmc/articles/PMC5642320/ /pubmed/28857856 http://dx.doi.org/10.1213/ANE.0000000000002410 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Anesthesia Research Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Hemostasis Schöchl, Herbert Grottke, Oliver Sutor, Ken Dony, Kieron Schreiber, Martin Ranucci, Marco Collins, Peter W. Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate |
title | Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate |
title_full | Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate |
title_fullStr | Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate |
title_full_unstemmed | Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate |
title_short | Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate |
title_sort | theoretical modeling of coagulation management with therapeutic plasma or prothrombin complex concentrate |
topic | Hemostasis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642320/ https://www.ncbi.nlm.nih.gov/pubmed/28857856 http://dx.doi.org/10.1213/ANE.0000000000002410 |
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