Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity

Tumors frequently display a glycolytic phenotype with increased flux through glycolysis and concomitant synthesis of lactate. To maintain glycolytic flux and prevent intracellular acidification, tumors efflux lactate via lactate transporters (MCT1-4). Inhibitors of lactate transport have the potenti...

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Detalles Bibliográficos
Autores principales: Curtis, Nicola J., Mooney, Lorraine, Hopcroft, Lorna, Michopoulos, Filippos, Whalley, Nichola, Zhong, Haihong, Murray, Clare, Logie, Armelle, Revill, Mitchell, Byth, Kate F., Benjamin, Amanda D., Firth, Mike A., Green, Stephen, Smith, Paul D., Critchlow, Susan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642474/
https://www.ncbi.nlm.nih.gov/pubmed/29050199
http://dx.doi.org/10.18632/oncotarget.18215

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