Cargando…

Application of in vivo imaging techniques to monitor therapeutic efficiency of PLX4720 in an experimental model of microsatellite instable colorectal cancer

OBJECTIVES: Patient-derived tumor cell lines are a powerful tool to analyze the sensitivity of individual tumors to specific therapies in mice. An essential prerequisite for such an approach are reliable quantitative techniques to monitor tumor progression in vivo. METHODS: We have employed HROC24 c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rohde, Sarah, Lindner, Tobias, Polei, Stefan, Stenzel, Jan, Borufka, Luise, Achilles, Sophie, Hartmann, Eric, Lange, Falko, Maletzki, Claudia, Linnebacher, Michael, Glass, Änne, Schwarzenböck, Sarah Marie, Kurth, Jens, Hohn, Alexander, Vollmar, Brigitte, Krause, Bernd Joachim, Jaster, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642514/ https://www.ncbi.nlm.nih.gov/pubmed/29050239 http://dx.doi.org/10.18632/oncotarget.19263

Ejemplares similares

ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition
por: Maruyama, Takeshi, et al.
Publicado: (2020)

Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells
por: Wallbaum, Peter, et al.
Publicado: (2018)

Selective BRAFV600E Inhibitor PLX4720, Requires TRAIL Assistance to Overcome Oncogenic PIK3CA Resistance
por: Oikonomou, Eftychia, et al.
Publicado: (2011)

Adaptive up-regulation of FOXD3 and resistance to PLX4032/4720-induced cell death in mutant B-RAF melanoma cells
por: Basile, Kevin J., et al.
Publicado: (2011)

[(68)Ga]pentixafor for CXCR4 imaging in a PC-3 prostate cancer xenograft model – comparison with [(18)F]FDG PET/CT, MRI and ex vivo receptor expression
por: Schwarzenböck, Sarah M., et al.
Publicado: (2017)

Targeting BRAF(V600E) with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer
por: Nucera, Carmelo, et al.
Publicado: (2011)

Anatomical MRI and [(18)F]FDG PET/CT imaging of Schistosoma mansoni in a NMRI mouse model
por: Lindner, Tobias, et al.
Publicado: (2020)

Microsatellite instability in hematological malignancies: Hypermutation vs. immune control—who is challenging who?
por: Maletzki, Claudia, et al.
Publicado: (2013)

Biological and Molecular Effects of Small Molecule Kinase Inhibitors on Low-Passage Human Colorectal Cancer Cell Lines
por: Lange, Falko, et al.
Publicado: (2014)

The BRAF-inhibitor PLX4720 inhibits CXCL8 secretion in BRAFV600E mutated and normal thyroid cells: a further anti-cancer effect of BRAF-inhibitors
por: Coperchini, Francesca, et al.
Publicado: (2019)

[(18)F]fallypride-PET/CT Analysis of the Dopamine D(2)/D(3) Receptor in the Hemiparkinsonian Rat Brain Following Intrastriatal Botulinum Neurotoxin A Injection
por: Mann, Teresa, et al.
Publicado: (2018)

In vitro studies implicate an imbalanced activation of dendritic cells in the pathogenesis of murine autoimmune pancreatitis
por: Borufka, Luise, et al.
Publicado: (2016)

An MSI Tumor Specific Frameshift Mutation in a Coding Microsatellite of MSH3 Encodes for HLA-A0201-Restricted CD8(+) Cytotoxic T Cell Epitopes
por: Garbe, Yvette, et al.
Publicado: (2011)

Effects of Withdrawal Rate on the Microstructure of Directionally Solidified GH4720Li Superalloys
por: Qu, Jinglong, et al.
Publicado: (2019)

One Year Follow-Up Risk Assessment in SKH-1 Mice and Wounds Treated with an Argon Plasma Jet
por: Schmidt, Anke, et al.
Publicado: (2017)

Quantitative Trait Locus Analysis Implicates CD4(+)/CD44(high) Memory T Cells in the Pathogenesis of Murine Autoimmune Pancreatitis
por: Bischof, Julia, et al.
Publicado: (2015)

Adoptive transfer of CD3(+) T cells and CD4(+) CD44(high) memory T cells induces autoimmune pancreatitis in MRL/MpJ mice
por: Ehlers, Luise, et al.
Publicado: (2018)

APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study
por: Kuhla, Angela, et al.
Publicado: (2017)

Longitudinal [(18)F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice
por: Kuhla, Angela, et al.
Publicado: (2020)

Tumor-infiltrating B cells: The ignored players in tumor immunology
por: Linnebacher, Michael, et al.
Publicado: (2012)

CircSMC3 regulates gastric cancer tumorigenesis by targeting miR‐4720‐3p/TJP1 axis
por: Xia, Tianfang, et al.
Publicado: (2020)

Direct-Current Electrical Field Stimulation of Patient-Derived Colorectal Cancer Cells
por: Lange, Falko, et al.
Publicado: (2023)

Blocking Autophagy in Cancer-Associated Fibroblasts Supports Chemotherapy of Pancreatic Cancer Cells
por: Zhang, Xianbin, et al.
Publicado: (2018)

Vitamin C sensitizes BRAF(V600E) thyroid cancer to PLX4032 via inhibiting the feedback activation of MAPK/ERK signal by PLX4032
por: Su, Xi, et al.
Publicado: (2021)

Streamlined Schemes for Dosimetry of (177)Lu-Labeled PSMA Targeting Radioligands in Therapy of Prostate Cancer
por: Kurth, Jens, et al.
Publicado: (2021)

A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel
por: Piawah, Sorbarikor, et al.
Publicado: (2019)

Plx1 is required for chromosomal DNA replication under stressful conditions
por: Trenz, Kristina, et al.
Publicado: (2008)

Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
por: Choi, Jaehyuk, et al.
Publicado: (2014)

External radiation exposure, excretion, and effective half-life in (177)Lu-PSMA-targeted therapies
por: Kurth, J., et al.
Publicado: (2018)

Bacterial immunotherapy of gastrointestinal tumors
por: Linnebacher, Michael, et al.
Publicado: (2011)

Combinations of TLR Ligands: A Promising Approach in Cancer Immunotherapy
por: Stier, Saskia, et al.
Publicado: (2013)

Editorial: Microsatellite and microsatellite instability
por: How-Kit, Alexandre, et al.
Publicado: (2023)

Putting PLX5622 into perspective: microglia in central nervous system viral infection
por: Spiteri, Alanna G., et al.
Publicado: (2022)

The mtDNA nt7778 G/T Polymorphism Augments Formation of Lymphocytic Foci but Does Not Aggravate Cerulein-Induced Acute Pancreatitis in Mice
por: Müller, Sarah, et al.
Publicado: (2014)

NOD2- and disease-specific gene expression profiles of peripheral blood mononuclear cells from Crohn’s disease patients
por: Schäffler, Holger, et al.
Publicado: (2018)

Young and healthy C57BL/6 J mice performing sprint interval training reveal gender- and site-specific changes to the cortical bone
por: Hollinski, Robin, et al.
Publicado: (2018)

PLX4032 resistance of patient-derived melanoma cells: crucial role of oxidative metabolism
por: Garbarino, Ombretta, et al.
Publicado: (2023)

Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
por: Mein, Nils, et al.
Publicado: (2023)

Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn’s disease
por: Elleisy, Nagi, et al.
Publicado: (2020)

Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley's Toxin
por: Maletzki, C., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_fh6dqhgfpmtnen78sbrgmvuvvn