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GMI ablates cancer stemness and cisplatin resistance in oral carcinomas stem cells through IL-6/Stat3 signaling inhibition
Cancer stem cells (CSCs) have been identified to exert tumor-initiating ability, resulting in the recurrence, metastasis and chemoresistance of oral squamous cell carcinomas. In the present study, we showed that GMI, an immunomodulatory protein from Ganoderma microsporum, induc ed a cytotoxic effect...
Autores principales: | Wang, Tung Yuan, Yu, Cheng-Chia, Hsieh, Pei-Ling, Liao, Yi-Wen, Yu, Chuan-Hang, Chou, Ming-Yung |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642565/ https://www.ncbi.nlm.nih.gov/pubmed/29050290 http://dx.doi.org/10.18632/oncotarget.19711 |
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