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Calyxin Y sensitizes cisplatin-sensitive and resistant hepatocellular carcinoma cells to cisplatin through apoptotic and autophagic cell death via SCF βTrCP-mediated eEF2K degradation

The down-regulation of eukaryotic elongation factor-2 kinase (eEF2K) is associated with an enhancement in the sensitivity of malignant cells to chemotherapeutic agents. In this study, we found that the silencing of eEF2K enhanced cisplatin (CDDP)-induced cytotoxicity in CDDP-sensitive (HepG2) and re...

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Detalles Bibliográficos
Autores principales:	Zhang, Chao, Lei, Jian-Li, Zhang, Hao, Xia, Yuan-Zheng, Yu, Pei, Yang, Lei, Kong, Ling-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642580/ https://www.ncbi.nlm.nih.gov/pubmed/29050305 http://dx.doi.org/10.18632/oncotarget.19883

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